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A compressed sensing based feature extraction method for identifying characteristic genes

  • Qufu Normal University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In current molecular biology, it becomes more and more important to identify characteristic genes closely correlated with a key biological process from gene expression data. In this paper, a novel compressed sensing (CS) based feature extraction method named CSGS is proposed to identify the characteristic genes. Considering the transposed gene expression matrix and class labels as sensing matrix and measurement vector, respectively, CS reconstruction is implemented by basis pursuit algorithm. Top ranking genes with high signal weights are retained as the characteristic genes. Experiments of CSGS are performed on leukemia data set and compared with other sparse methods. Results demonstrate that CSGS is effective in identifying characteristic genes, and is not sensitive to parameters. CSGS could offer a simple way for feature extraction and provide more clues for biologists.

Original languageEnglish
Title of host publicationIntelligent Computing Theories and Application - 12th International Conference, ICIC 2016, Proceedings
EditorsDe-Shuang Huang, Kang-Hyun Jo
PublisherSpringer Verlag
Pages67-77
Number of pages11
ISBN (Print)9783319422930
DOIs
StatePublished - 2016
Externally publishedYes
Event12th International Conference on Intelligent Computing Theories and Application, ICIC 2016 - Lanzhou, China
Duration: 2 Aug 20165 Aug 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9772
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference12th International Conference on Intelligent Computing Theories and Application, ICIC 2016
Country/TerritoryChina
CityLanzhou
Period2/08/165/08/16

Keywords

  • Characteristic genes
  • Compressed sensing
  • Feature extraction
  • Gene expression data

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