A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

Cheng Ouyang; Lei Chen; Thomas W. Rees; Yu Chen; Jiankang Liu; Liangnian Ji; Jiangang Long; Hui Chao

doi:10.1039/c8cc02795a

A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

Cheng Ouyang
, Lei Chen
, Thomas W. Rees
, Yu Chen
, Jiankang Liu
, Liangnian Ji
, Jiangang Long
, Hui Chao

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

Original language	English
Pages (from-to)	6268-6271
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	49
DOIs	https://doi.org/10.1039/c8cc02795a
State	Published - 2018
Externally published	Yes

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@article{fde19588948748a2b2bb859641e75750,

title = "A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells",

abstract = "A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.",

author = "Cheng Ouyang and Lei Chen and Rees, \{Thomas W.\} and Yu Chen and Jiankang Liu and Liangnian Ji and Jiangang Long and Hui Chao",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c8cc02795a",

language = "英语",

volume = "54",

pages = "6268--6271",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

AU - Ouyang, Cheng

AU - Chen, Lei

AU - Rees, Thomas W.

AU - Chen, Yu

AU - Liu, Jiankang

AU - Ji, Liangnian

AU - Long, Jiangang

AU - Chao, Hui

PY - 2018

Y1 - 2018

N2 - A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

AB - A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

UR - https://www.scopus.com/pages/publications/85048644254

U2 - 10.1039/c8cc02795a

DO - 10.1039/c8cc02795a

M3 - 文章

C2 - 29850704

AN - SCOPUS:85048644254

SN - 1359-7345

VL - 54

SP - 6268

EP - 6271

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

Abstract

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