TY - JOUR
T1 - A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment
AU - Huang, Xiaodan
AU - Huang, Pengcheng
AU - Huang, Lu
AU - Hu, Zhengfang
AU - Liu, Xianwei
AU - Shen, Jiawei
AU - Xi, Yue
AU - Yang, Yan
AU - Fu, Yunwei
AU - Tao, Qian
AU - Lin, Song
AU - Xu, Anding
AU - Xu, Fuqiang
AU - Xue, Tian
AU - So, Kwok Fai
AU - Li, Haohong
AU - Ren, Chaoran
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/1/20
Y1 - 2021/1/20
N2 - Light exerts profound effects on cognitive functions across species, including humans. However, the neuronal mechanisms underlying the effects of light on cognitive functions are poorly understood. In this study, we show that long-term exposure to bright-light treatment promotes spatial memory through a di-synaptic visual circuit related to the nucleus reuniens (Re). Specifically, a subset of SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate CaMKIIα neurons in the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which in turn activate CaMKIIα neurons in the Re. Specific activation of vLGN/IGL-projecting RGCs, activation of Re-projecting vLGN/IGL neurons, or activation of postsynaptic Re neurons is sufficient to promote spatial memory. Furthermore, we demonstrate that the spatial-memory-promoting effects of light treatment are dependent on the activation of vLGN/IGL-projecting RGCs, Re-projecting vLGN/IGL neurons, and Re neurons. Our results reveal a dedicated subcortical visual circuit that mediates the spatial-memory-promoting effects of light treatment.
AB - Light exerts profound effects on cognitive functions across species, including humans. However, the neuronal mechanisms underlying the effects of light on cognitive functions are poorly understood. In this study, we show that long-term exposure to bright-light treatment promotes spatial memory through a di-synaptic visual circuit related to the nucleus reuniens (Re). Specifically, a subset of SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate CaMKIIα neurons in the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which in turn activate CaMKIIα neurons in the Re. Specific activation of vLGN/IGL-projecting RGCs, activation of Re-projecting vLGN/IGL neurons, or activation of postsynaptic Re neurons is sufficient to promote spatial memory. Furthermore, we demonstrate that the spatial-memory-promoting effects of light treatment are dependent on the activation of vLGN/IGL-projecting RGCs, Re-projecting vLGN/IGL neurons, and Re neurons. Our results reveal a dedicated subcortical visual circuit that mediates the spatial-memory-promoting effects of light treatment.
UR - https://www.scopus.com/pages/publications/85096881262
U2 - 10.1016/j.neuron.2020.10.023
DO - 10.1016/j.neuron.2020.10.023
M3 - 文章
C2 - 33171117
AN - SCOPUS:85096881262
SN - 0896-6273
VL - 109
SP - 347-362.e7
JO - Neuron
JF - Neuron
IS - 2
ER -