Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans

Xinan Meng; Qingxian Yang; Xinghai Yu; Jinghua Zhou; Xuecong Ren; Yu Zhou; Suhong Xu

doi:10.1016/j.devcel.2020.06.027

Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans

Xinan Meng
, Qingxian Yang
, Xinghai Yu
, Jinghua Zhou
, Xuecong Ren
, Yu Zhou
, Suhong Xu

School of Medicine
Wuhan University
The Zhejiang University-University of Edinburgh Institute

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The ability to repair plasma membrane damage is critical to all eukaryotic cells. Meng et al. demonstrate that damage-induced F-actin and ESCRT III signals trigger sequential recruitment of the fusogens syntaxin-2 and EFF-1 to facilitate repair of the plasma membrane in C. elegans skin cells.

Original language	English
Pages (from-to)	624-638.e5
Journal	Developmental Cell
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2020.06.027
State	Published - 14 Sep 2020
Externally published	Yes

Keywords

EFF-1
ESCRT
SYX-2
actin polymerization
fusogen
membrane fusion
plasma membrane repair
t-SNARE
wound healing

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10.1016/j.devcel.2020.06.027

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title = "Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans",

abstract = "The ability to repair plasma membrane damage is critical to all eukaryotic cells. Meng et al. demonstrate that damage-induced F-actin and ESCRT III signals trigger sequential recruitment of the fusogens syntaxin-2 and EFF-1 to facilitate repair of the plasma membrane in C. elegans skin cells.",

keywords = "EFF-1, ESCRT, SYX-2, actin polymerization, fusogen, membrane fusion, plasma membrane repair, t-SNARE, wound healing",

author = "Xinan Meng and Qingxian Yang and Xinghai Yu and Jinghua Zhou and Xuecong Ren and Yu Zhou and Suhong Xu",

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year = "2020",

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doi = "10.1016/j.devcel.2020.06.027",

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T1 - Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans

AU - Meng, Xinan

AU - Yang, Qingxian

AU - Yu, Xinghai

AU - Zhou, Jinghua

AU - Ren, Xuecong

AU - Zhou, Yu

AU - Xu, Suhong

PY - 2020/9/14

Y1 - 2020/9/14

N2 - The ability to repair plasma membrane damage is critical to all eukaryotic cells. Meng et al. demonstrate that damage-induced F-actin and ESCRT III signals trigger sequential recruitment of the fusogens syntaxin-2 and EFF-1 to facilitate repair of the plasma membrane in C. elegans skin cells.

AB - The ability to repair plasma membrane damage is critical to all eukaryotic cells. Meng et al. demonstrate that damage-induced F-actin and ESCRT III signals trigger sequential recruitment of the fusogens syntaxin-2 and EFF-1 to facilitate repair of the plasma membrane in C. elegans skin cells.

KW - EFF-1

KW - ESCRT

KW - SYX-2

KW - actin polymerization

KW - fusogen

KW - membrane fusion

KW - plasma membrane repair

KW - t-SNARE

KW - wound healing

UR - https://www.scopus.com/pages/publications/85089292785

U2 - 10.1016/j.devcel.2020.06.027

DO - 10.1016/j.devcel.2020.06.027

M3 - 文章

C2 - 32668210

AN - SCOPUS:85089292785

SN - 1534-5807

VL - 54

SP - 624-638.e5

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Actin Polymerization and ESCRT Trigger Recruitment of the Fusogens Syntaxin-2 and EFF-1 to Promote Membrane Repair in C. elegans

Abstract

Keywords

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