Agaricus blazei Murill polysaccharides alleviate oxidative stress and inflammatory responses against liver and lung injury

As a kind of well-known edible mushroom, the medicinal values of Agaricus blazei Murill also have been well acknowledged. There is no efficient treatment strategy for multiple organ dysfunction syndrome (MODS) so far, a crucial cause of clinical death. The present work was designed to evaluate the beneficially protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung against zymosan (ZY)-induced MODS related damages. The MODS mice were successfully established by given one-time injection of zymosan solution (500 mg/kg) intraperitoneally. The in vivo results demonstrated that ABMP could improve the 10-day survival rate, ease abnormal physiological behavior and alleviate tissues oxidative stress in MODS mice. Besides, ABMP showed potential effects on attenuating the functional impairments of liver and lung. Meanwhile, ABMP effectively inhibited the activation of NF-κB signaling pathway and reduced the expressions of inflammatory cytokines, including TNF-α, IL-1β, IL-6, COX-2 and PGE-2. Additionally, the structural characterizations showed that the significant function of ABMP was possibly related with the β-pyranose configuration with a triple-helical structure composing of glucose mainly with the proper molecular weights of 12.26 kDa. These findings demonstrated that ABMP exhibited potential protections against liver and lung damages in the ZY-induced MODS mice, providing more theoretical basis and reference significance for the exploration of biological activity of A. blazei Murill.