An electrochemiluminescence aptasensor based on Ti₃C₂ QDs-1T/2H MoS₂ nano-hybrid material for the highly sensitive detection of lincomycin

Developing a highly selective and sensitive analysis strategy for lincomycin (LIN) is of great significance for environmental protection and food safety. Herein, we reported a novel electrochemiluminescence (ECL) aptasensor based on Ti₃C₂ QDs-1T/2H MoS₂ nano-hybrid luminophore for detection of LIN. The hybridization of Ti₃C₂ QDs and 1T/2H MoS₂ endowed nanocomposite with structural and compositional advantages for boosting the ECL performance of QDs by about three times. This enhancement could be attributed to the remarkable electrocatalytic activity and high conductivity exhibited by 1T/2H MoS₂. Secondly, the great surface area of 1T/2H MoS₂ is conducive to the high dispersion of Ti₃C₂ QDs, and its good conductivity could promote charge transfer. On the other hand, the excellent catalytic performance of 1T/2H MoS₂ could facilitate the reduction of S₂O₈²⁻ to produce more radical, which significantly enhance the ECL signal of Ti₃C₂ QDs. Given these features, a sensor for detection of LIN was established based on specific recognition between target and aptamer. The sensor showed a good linear relationship (0.05 ng mL⁻¹ ∼100 μg mL⁻¹) with a detection limit as low as 0.02 ng mL⁻¹. It is worth noting that this work has been validated in testing milk samples, exhibiting great potential application prospects in food analysis.