Abstract
Along with the rapid development of high-throughput sequencing technology, a large amount of multi-omics data sets are generated, which provide more opportunities to understand the mechanism of complex diseases. In this study, an improved particle swarm optimization with dynamic scale-free network, named DSFPSO, is proposed for detecting multi-omics features. The highlights of DSFPSO are the introduced scale-free network and velocity updating strategies. The scale-free network is employed to DSFPSO as its population structure, which can dynamically adjust the iteration processes. Three types of velocity updating strategies are used in DSFPSO for fully considering the heterogeneity of particles and their neighbors. Both gene function analysis and pathway analysis on colorectal cancer (CRC) data show that DSFPSO can detect CRC-associated features effectively.
| Original language | English |
|---|---|
| Title of host publication | Bioinformatics Research and Applications - 14th International Symposium, ISBRA 2018, Proceedings |
| Editors | Fa Zhang, Shihua Zhang, Zhipeng Cai, Pavel Skums |
| Publisher | Springer Verlag |
| Pages | 26-37 |
| Number of pages | 12 |
| ISBN (Print) | 9783319949673 |
| DOIs | |
| State | Published - 2018 |
| Externally published | Yes |
| Event | 14th International Symposium on Bioinformatics Research and Applications, ISBRA 2018 - Beijing, China Duration: 8 Jun 2018 → 11 Jun 2018 |
Publication series
| Name | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
|---|---|
| Volume | 10847 LNBI |
| ISSN (Print) | 0302-9743 |
| ISSN (Electronic) | 1611-3349 |
Conference
| Conference | 14th International Symposium on Bioinformatics Research and Applications, ISBRA 2018 |
|---|---|
| Country/Territory | China |
| City | Beijing |
| Period | 8/06/18 → 11/06/18 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Colorectal cancer
- Dynamic scale-free network
- Multi-omics
- Mutual information
- Particle swarm optimization
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