An improved particle swarm optimization with dynamic scale-free network for detecting multi-omics features

  • Huiyu Li
  • , Sheng Jun Li
  • , Junliang Shang
  • , Jin Xing Liu
  • , Chun Hou Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Along with the rapid development of high-throughput sequencing technology, a large amount of multi-omics data sets are generated, which provide more opportunities to understand the mechanism of complex diseases. In this study, an improved particle swarm optimization with dynamic scale-free network, named DSFPSO, is proposed for detecting multi-omics features. The highlights of DSFPSO are the introduced scale-free network and velocity updating strategies. The scale-free network is employed to DSFPSO as its population structure, which can dynamically adjust the iteration processes. Three types of velocity updating strategies are used in DSFPSO for fully considering the heterogeneity of particles and their neighbors. Both gene function analysis and pathway analysis on colorectal cancer (CRC) data show that DSFPSO can detect CRC-associated features effectively.

Original languageEnglish
Title of host publicationBioinformatics Research and Applications - 14th International Symposium, ISBRA 2018, Proceedings
EditorsFa Zhang, Shihua Zhang, Zhipeng Cai, Pavel Skums
PublisherSpringer Verlag
Pages26-37
Number of pages12
ISBN (Print)9783319949673
DOIs
StatePublished - 2018
Externally publishedYes
Event14th International Symposium on Bioinformatics Research and Applications, ISBRA 2018 - Beijing, China
Duration: 8 Jun 201811 Jun 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10847 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference14th International Symposium on Bioinformatics Research and Applications, ISBRA 2018
Country/TerritoryChina
CityBeijing
Period8/06/1811/06/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Colorectal cancer
  • Dynamic scale-free network
  • Multi-omics
  • Mutual information
  • Particle swarm optimization

Fingerprint

Dive into the research topics of 'An improved particle swarm optimization with dynamic scale-free network for detecting multi-omics features'. Together they form a unique fingerprint.

Cite this