Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

Yongning Xin; Wei Li; Linlin Lu; Li Zhou; David W. Victor; Shiying Xuan

doi:10.1007/s11802-016-3124-4

Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

Yongning Xin
, Wei Li
, Linlin Lu
, Li Zhou
, David W. Victor
, Shiying Xuan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg⁻¹), middle dose SJAMP (40 mg kg⁻¹), high dose SJAMP (50 mg kg⁻¹) and IFN (45 IU kg⁻¹) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

Original language	English
Pages (from-to)	719-725
Number of pages	7
Journal	Journal of Ocean University of China
Volume	15
Issue number	4
DOIs	https://doi.org/10.1007/s11802-016-3124-4
State	Published - 1 Aug 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Stichopus japonicus acid mucopolysaccharide
antiviral
hepatitis B virus
transgenic mice

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10.1007/s11802-016-3124-4

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title = "Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice",

abstract = "Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.",

keywords = "Stichopus japonicus acid mucopolysaccharide, antiviral, hepatitis B virus, transgenic mice",

author = "Yongning Xin and Wei Li and Linlin Lu and Li Zhou and Victor, \{David W.\} and Shiying Xuan",

note = "Publisher Copyright: {\textcopyright} 2016, Science Press, Ocean University of China and Springer-Verlag Berlin Heidelberg.",

year = "2016",

month = aug,

day = "1",

doi = "10.1007/s11802-016-3124-4",

language = "英语",

volume = "15",

pages = "719--725",

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TY - JOUR

T1 - Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

AU - Xin, Yongning

AU - Li, Wei

AU - Lu, Linlin

AU - Zhou, Li

AU - Victor, David W.

AU - Xuan, Shiying

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

AB - Hepatitis B virus (HBV) is a significant global pathogen and efficient cure for HBV patients is still a challenging goal. We previously reported that acidic mucopolysaccharide from stichopus japonicus selenka (SJAMP) could inhibit HBsAg and HBeAg expression in vitro. However, the potential anti-HBV effects of SJAMP in vivo have not yet been explored. In this study, we show that SJAMP exhibits potent anti-HBV activity in HBV transgenic mice in a dose-dependent manner. Specifically, sixty HBV transgenic male BALB/c mice were randomly selected to receive the treatment of PBS, low dose SJAMP (30 mg kg−1), middle dose SJAMP (40 mg kg−1), high dose SJAMP (50 mg kg−1) and IFN (45 IU kg−1) for 30 d. SJAMP treatment suppressed serum HBV-DNA, and liver HBsAg and HBcAg levels in HBV-transgenic mice. The present study highlights the potential application of SJAMP in HBV therapy.

KW - Stichopus japonicus acid mucopolysaccharide

KW - antiviral

KW - hepatitis B virus

KW - transgenic mice

UR - https://www.scopus.com/pages/publications/84978140852

U2 - 10.1007/s11802-016-3124-4

DO - 10.1007/s11802-016-3124-4

M3 - 文章

AN - SCOPUS:84978140852

SN - 1672-5182

VL - 15

SP - 719

EP - 725

JO - Journal of Ocean University of China

JF - Journal of Ocean University of China

IS - 4

ER -

Antiviral effects of Stichopus japonicus acid mucopolysaccharide on hepatitis B virus transgenic mice

Abstract

UN SDGs

Keywords

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