ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

Jie Ran; Min Liu; Jie Feng; Haixia Li; Huixian Ma; Ting Song; Yu Cao; Peng Zhou; Yuhan Wu; Yunfan Yang; Yang Yang; Fan Yu; Heng Guo; Liang Zhang; Songbo Xie; Dengwen Li; Jinmin Gao; Xiaomin Zhang; Xueliang Zhu; Jun Zhou

doi:10.1016/j.devcel.2020.03.010

ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

Jie Ran
, Min Liu
, Jie Feng
, Haixia Li
, Huixian Ma
, Ting Song
, Yu Cao
, Peng Zhou
, Yuhan Wu
, Yunfan Yang
, Yang Yang
, Fan Yu
, Heng Guo
, Liang Zhang
, Songbo Xie
, Dengwen Li
, Jinmin Gao
, Xiaomin Zhang
, Xueliang Zhu
, Jun Zhou

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Using the oxygen-induced retinopathy (OIR) mouse model for retinopathy of prematurity (ROP), Ran et al. show that oxygen changes trigger ASK1 activation to phosphorylate HDAC6, blocking HDAC6 ubiquitination by VHL and proteasomal degradation. HDAC6 then drives photoreceptor connecting cilium disassembly, which they demonstrate is an early event in OIR pathogenesis.

Original language	English
Pages (from-to)	287-299.e5
Journal	Developmental Cell
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2020.03.010
State	Published - 4 May 2020
Externally published	Yes

Keywords

apoptosis signal-regulating kinase 1
connecting cilium
histone deacetylase 6
oxygen-induced retinopathy
phosphorylation
photoreceptor
proteasome
retina
retinopathy of prematurity
ubiquitination

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10.1016/j.devcel.2020.03.010

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Ran, J., Liu, M., Feng, J., Li, H., Ma, H., Song, T., Cao, Y., Zhou, P., Wu, Y., Yang, Y., Yang, Y., Yu, F., Guo, H., Zhang, L., Xie, S., Li, D., Gao, J., Zhang, X., Zhu, X., & Zhou, J. (2020). ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia. Developmental Cell, 53(3), 287-299.e5. https://doi.org/10.1016/j.devcel.2020.03.010

@article{7937291937aa409da1afa4bc2bcc8394,

title = "ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia",

abstract = "Using the oxygen-induced retinopathy (OIR) mouse model for retinopathy of prematurity (ROP), Ran et al. show that oxygen changes trigger ASK1 activation to phosphorylate HDAC6, blocking HDAC6 ubiquitination by VHL and proteasomal degradation. HDAC6 then drives photoreceptor connecting cilium disassembly, which they demonstrate is an early event in OIR pathogenesis.",

keywords = "apoptosis signal-regulating kinase 1, connecting cilium, histone deacetylase 6, oxygen-induced retinopathy, phosphorylation, photoreceptor, proteasome, retina, retinopathy of prematurity, ubiquitination",

author = "Jie Ran and Min Liu and Jie Feng and Haixia Li and Huixian Ma and Ting Song and Yu Cao and Peng Zhou and Yuhan Wu and Yunfan Yang and Yang Yang and Fan Yu and Heng Guo and Liang Zhang and Songbo Xie and Dengwen Li and Jinmin Gao and Xiaomin Zhang and Xueliang Zhu and Jun Zhou",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = may,

day = "4",

doi = "10.1016/j.devcel.2020.03.010",

language = "英语",

volume = "53",

pages = "287--299.e5",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "3",

}

Ran, J, Liu, M, Feng, J, Li, H, Ma, H, Song, T, Cao, Y, Zhou, P, Wu, Y, Yang, Y, Yang, Y, Yu, F, Guo, H, Zhang, L, Xie, S, Li, D, Gao, J, Zhang, X, Zhu, X & Zhou, J 2020, 'ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia', Developmental Cell, vol. 53, no. 3, pp. 287-299.e5. https://doi.org/10.1016/j.devcel.2020.03.010

TY - JOUR

T1 - ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

AU - Ran, Jie

AU - Liu, Min

AU - Feng, Jie

AU - Li, Haixia

AU - Ma, Huixian

AU - Song, Ting

AU - Cao, Yu

AU - Zhou, Peng

AU - Wu, Yuhan

AU - Yang, Yunfan

AU - Yang, Yang

AU - Yu, Fan

AU - Guo, Heng

AU - Zhang, Liang

AU - Xie, Songbo

AU - Li, Dengwen

AU - Gao, Jinmin

AU - Zhang, Xiaomin

AU - Zhu, Xueliang

AU - Zhou, Jun

PY - 2020/5/4

Y1 - 2020/5/4

N2 - Using the oxygen-induced retinopathy (OIR) mouse model for retinopathy of prematurity (ROP), Ran et al. show that oxygen changes trigger ASK1 activation to phosphorylate HDAC6, blocking HDAC6 ubiquitination by VHL and proteasomal degradation. HDAC6 then drives photoreceptor connecting cilium disassembly, which they demonstrate is an early event in OIR pathogenesis.

AB - Using the oxygen-induced retinopathy (OIR) mouse model for retinopathy of prematurity (ROP), Ran et al. show that oxygen changes trigger ASK1 activation to phosphorylate HDAC6, blocking HDAC6 ubiquitination by VHL and proteasomal degradation. HDAC6 then drives photoreceptor connecting cilium disassembly, which they demonstrate is an early event in OIR pathogenesis.

KW - apoptosis signal-regulating kinase 1

KW - connecting cilium

KW - histone deacetylase 6

KW - oxygen-induced retinopathy

KW - phosphorylation

KW - photoreceptor

KW - proteasome

KW - retina

KW - retinopathy of prematurity

KW - ubiquitination

UR - https://www.scopus.com/pages/publications/85083765064

U2 - 10.1016/j.devcel.2020.03.010

DO - 10.1016/j.devcel.2020.03.010

M3 - 文章

C2 - 32275885

AN - SCOPUS:85083765064

SN - 1534-5807

VL - 53

SP - 287-299.e5

JO - Developmental Cell

JF - Developmental Cell

IS - 3

ER -

ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia

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