Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Kun Yang; Yu Peng Feng; Yun Qing Li

doi:10.1016/S0006-8993(01)02293-4

Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Kun Yang
, Yu Peng Feng
, Yun Qing Li

Fourth Military Medical University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We investigated the action of baclofen, an agonist for GABA_B receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABA_A receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABA_B receptor in spinal dorsal horn.

Original language	English
Pages (from-to)	320-323
Number of pages	4
Journal	Brain Research
Volume	900
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02293-4
State	Published - 11 May 2001
Externally published	Yes

Keywords

Baclofen
Inhibitory postsynaptic current
Rat
Spinal cord
Substantia gelatinosa
Whole-cell voltage-clamp recording

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10.1016/S0006-8993(01)02293-4

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title = "Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice",

abstract = "We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0\% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4\% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn.",

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T1 - Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

AU - Yang, Kun

AU - Feng, Yu Peng

AU - Li, Yun Qing

PY - 2001/5/11

Y1 - 2001/5/11

N2 - We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn.

AB - We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn.

KW - Baclofen

KW - Inhibitory postsynaptic current

KW - Rat

KW - Spinal cord

KW - Substantia gelatinosa

KW - Whole-cell voltage-clamp recording

UR - https://www.scopus.com/pages/publications/0035844075

U2 - 10.1016/S0006-8993(01)02293-4

DO - 10.1016/S0006-8993(01)02293-4

M3 - 文章

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AN - SCOPUS:0035844075

SN - 0006-8993

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EP - 323

JO - Brain Research

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ER -

Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Abstract

Keywords

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