TY - JOUR
T1 - Bio-multifunctional alginate/chitosan/fucoidan sponges with enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing
AU - Hao, Yuanping
AU - Zhao, Wenwen
AU - Zhang, Liyu
AU - Zeng, Xi
AU - Sun, Zhanyi
AU - Zhang, Demeng
AU - Shen, Peili
AU - Li, Zhixin
AU - Han, Yantao
AU - Li, Peifeng
AU - Zhou, Qihui
N1 - Publisher Copyright:
© 2020
PY - 2020/8
Y1 - 2020/8
N2 - Developing bio-multifunctional wound dressings with excellent hemostasis, antibacterial, anti-inflammatory, enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing is highly valuable in clinical application. Herein, bio-multifunctional composite sponges were prepared by coupling alginate and chitosan with fucoidan through electrostatic interaction, Ca2+ crosslinking, and lyophilization processes. The prepared alginate/chitosan/fucoidan (ACF) sponges display excellent elastic properties, preserving their shape even after bending and compressive strain without failure. The ACF sponge containing 10% fucoidan (ACF-1) shows better hemostatic and antibacterial performances, and significantly promotes wound closure in a rat full-thickness wounds model compared to the alginate/chitosan group and ACF sponge containing 30% fucoidan. Furthermore, the ACF-1 sponge greatly facilitates the epithelialization and the formation of collagen in the dermis, promotes the hair follicle regeneration, enhances vascularization by upregulating the protein expression of CD31, and reduces inflammation by downregulating the protein expression of TNF-α. This work suggests that ACF sponges with a certain amount of fucoidan display great potential for the treatment of full-thickness skin repair.
AB - Developing bio-multifunctional wound dressings with excellent hemostasis, antibacterial, anti-inflammatory, enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing is highly valuable in clinical application. Herein, bio-multifunctional composite sponges were prepared by coupling alginate and chitosan with fucoidan through electrostatic interaction, Ca2+ crosslinking, and lyophilization processes. The prepared alginate/chitosan/fucoidan (ACF) sponges display excellent elastic properties, preserving their shape even after bending and compressive strain without failure. The ACF sponge containing 10% fucoidan (ACF-1) shows better hemostatic and antibacterial performances, and significantly promotes wound closure in a rat full-thickness wounds model compared to the alginate/chitosan group and ACF sponge containing 30% fucoidan. Furthermore, the ACF-1 sponge greatly facilitates the epithelialization and the formation of collagen in the dermis, promotes the hair follicle regeneration, enhances vascularization by upregulating the protein expression of CD31, and reduces inflammation by downregulating the protein expression of TNF-α. This work suggests that ACF sponges with a certain amount of fucoidan display great potential for the treatment of full-thickness skin repair.
KW - Composite sponges
KW - Fucoidan
KW - Marine polysaccharide
KW - Wound healing
UR - https://www.scopus.com/pages/publications/85086074203
U2 - 10.1016/j.matdes.2020.108863
DO - 10.1016/j.matdes.2020.108863
M3 - 文章
AN - SCOPUS:85086074203
SN - 0264-1275
VL - 193
JO - Materials and Design
JF - Materials and Design
M1 - 108863
ER -