C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

Ze Gang Ma; Jun Wang; Hong Jiang; Jun Xia Xie; Lei Chen

doi:10.1016/j.neulet.2005.02.065

C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

Ze Gang Ma
, Jun Wang
, Hong Jiang
, Jun Xia Xie
, Lei Chen

Medical College of Qingdao University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Neuroscience Letters
Volume	382
Issue number	1-2
DOIs	https://doi.org/10.1016/j.neulet.2005.02.065
State	Published - 1 Jul 2005
Externally published	Yes

Keywords

Alzheimer's disease
C31
Voltage-gated calcium channel

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10.1016/j.neulet.2005.02.065

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title = "C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells",

abstract = "C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.",

keywords = "Alzheimer's disease, C31, Voltage-gated calcium channel",

author = "Ma, \{Ze Gang\} and Jun Wang and Hong Jiang and Xie, \{Jun Xia\} and Lei Chen",

year = "2005",

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doi = "10.1016/j.neulet.2005.02.065",

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TY - JOUR

T1 - C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

AU - Ma, Ze Gang

AU - Wang, Jun

AU - Jiang, Hong

AU - Xie, Jun Xia

AU - Chen, Lei

PY - 2005/7/1

Y1 - 2005/7/1

N2 - C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.

AB - C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.

KW - Alzheimer's disease

KW - C31

KW - Voltage-gated calcium channel

UR - https://www.scopus.com/pages/publications/19444371487

U2 - 10.1016/j.neulet.2005.02.065

DO - 10.1016/j.neulet.2005.02.065

M3 - 文章

C2 - 15911130

AN - SCOPUS:19444371487

SN - 0304-3940

VL - 382

SP - 102

EP - 105

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

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Keywords

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