Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer

Santasree Banerjee; Xianxiang Zhang; Shan Kuang; Jigang Wang; Lei Li; Guangyi Fan; Yonglun Luo; Shuai Sun; Peng Han; Qingyao Wu; Shujian Yang; Xiaobin Ji; Yong Li; Li Deng; Xiaofen Tian; Zhiwei Wang; Yue Zhang; Kui Wu; Shida Zhu; Lars Bolund; Huanming Yang; Xun Xu; Junnian Liu; Yun Lu; Xin Liu

doi:10.1016/j.isci.2021.102718

Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer

Santasree Banerjee
, Xianxiang Zhang
, Shan Kuang
, Jigang Wang
, Lei Li
, Guangyi Fan
, Yonglun Luo
, Shuai Sun
, Peng Han
, Qingyao Wu
, Shujian Yang
, Xiaobin Ji
, Yong Li
, Li Deng
, Xiaofen Tian
, Zhiwei Wang
, Yue Zhang
, Kui Wu
, Shida Zhu
, Lars Bolund

Huanming Yang, Xun Xu, Junnian Liu, Yun Lu, Xin Liu

BGI-Shenzhen
Qingdao University
University of Chinese Academy of Sciences
Aarhus University
Zhejiang University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Tumor multiregion sequencing reveals intratumor heterogeneity (ITH) and clonal evolution playing a key role in tumor progression and metastases. Large-scale high-depth multiregional sequencing of colorectal cancer, comparative analysis among patients with right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer (RC), as well as the study of lymph node metastasis (LN) with extranodal tumor deposits (ENTDs) from evolutionary perspective remain weakly explored. Here, we recruited 68 patients with RCC (18), LCC (20), and RC (30). We performed high-depth whole-exome sequencing of 206 tumor regions including 176 primary tumors, 19 LN, and 11 ENTD samples. Our results showed ITH with a Darwinian pattern of evolution and the evolution pattern of LCC and RC was more complex and divergent than RCC. Genetic and evolutionary evidences found that both LN and ENTD originated from different clones. Moreover, ENTD was a distinct entity from LN and evolved later.

Original language	English
Article number	102718
Journal	iScience
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/j.isci.2021.102718
State	Published - 23 Jul 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer Systems Biology
Evolutionary Biology
Genomics

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10.1016/j.isci.2021.102718

Cite this

Banerjee, S., Zhang, X., Kuang, S., Wang, J., Li, L., Fan, G., Luo, Y., Sun, S., Han, P., Wu, Q., Yang, S., Ji, X., Li, Y., Deng, L., Tian, X., Wang, Z., Zhang, Y., Wu, K., Zhu, S., ... Liu, X. (2021). Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer. iScience, 24(7), Article 102718. https://doi.org/10.1016/j.isci.2021.102718

@article{7eeb8243ac71428f9a2e105ac1316b6f,

title = "Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer",

abstract = "Tumor multiregion sequencing reveals intratumor heterogeneity (ITH) and clonal evolution playing a key role in tumor progression and metastases. Large-scale high-depth multiregional sequencing of colorectal cancer, comparative analysis among patients with right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer (RC), as well as the study of lymph node metastasis (LN) with extranodal tumor deposits (ENTDs) from evolutionary perspective remain weakly explored. Here, we recruited 68 patients with RCC (18), LCC (20), and RC (30). We performed high-depth whole-exome sequencing of 206 tumor regions including 176 primary tumors, 19 LN, and 11 ENTD samples. Our results showed ITH with a Darwinian pattern of evolution and the evolution pattern of LCC and RC was more complex and divergent than RCC. Genetic and evolutionary evidences found that both LN and ENTD originated from different clones. Moreover, ENTD was a distinct entity from LN and evolved later.",

keywords = "Cancer Systems Biology, Evolutionary Biology, Genomics",

author = "Santasree Banerjee and Xianxiang Zhang and Shan Kuang and Jigang Wang and Lei Li and Guangyi Fan and Yonglun Luo and Shuai Sun and Peng Han and Qingyao Wu and Shujian Yang and Xiaobin Ji and Yong Li and Li Deng and Xiaofen Tian and Zhiwei Wang and Yue Zhang and Kui Wu and Shida Zhu and Lars Bolund and Huanming Yang and Xun Xu and Junnian Liu and Yun Lu and Xin Liu",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = jul,

day = "23",

doi = "10.1016/j.isci.2021.102718",

language = "英语",

volume = "24",

journal = "iScience",

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Banerjee, S, Zhang, X, Kuang, S, Wang, J, Li, L, Fan, G, Luo, Y, Sun, S, Han, P, Wu, Q, Yang, S, Ji, X, Li, Y, Deng, L, Tian, X, Wang, Z, Zhang, Y, Wu, K, Zhu, S, Bolund, L, Yang, H, Xu, X, Liu, J, Lu, Y & Liu, X 2021, 'Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer', iScience, vol. 24, no. 7, 102718. https://doi.org/10.1016/j.isci.2021.102718

TY - JOUR

T1 - Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer

AU - Banerjee, Santasree

AU - Zhang, Xianxiang

AU - Kuang, Shan

AU - Wang, Jigang

AU - Li, Lei

AU - Fan, Guangyi

AU - Luo, Yonglun

AU - Sun, Shuai

AU - Han, Peng

AU - Wu, Qingyao

AU - Yang, Shujian

AU - Ji, Xiaobin

AU - Li, Yong

AU - Deng, Li

AU - Tian, Xiaofen

AU - Wang, Zhiwei

AU - Zhang, Yue

AU - Wu, Kui

AU - Zhu, Shida

AU - Bolund, Lars

AU - Yang, Huanming

AU - Xu, Xun

AU - Liu, Junnian

AU - Lu, Yun

AU - Liu, Xin

PY - 2021/7/23

Y1 - 2021/7/23

N2 - Tumor multiregion sequencing reveals intratumor heterogeneity (ITH) and clonal evolution playing a key role in tumor progression and metastases. Large-scale high-depth multiregional sequencing of colorectal cancer, comparative analysis among patients with right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer (RC), as well as the study of lymph node metastasis (LN) with extranodal tumor deposits (ENTDs) from evolutionary perspective remain weakly explored. Here, we recruited 68 patients with RCC (18), LCC (20), and RC (30). We performed high-depth whole-exome sequencing of 206 tumor regions including 176 primary tumors, 19 LN, and 11 ENTD samples. Our results showed ITH with a Darwinian pattern of evolution and the evolution pattern of LCC and RC was more complex and divergent than RCC. Genetic and evolutionary evidences found that both LN and ENTD originated from different clones. Moreover, ENTD was a distinct entity from LN and evolved later.

AB - Tumor multiregion sequencing reveals intratumor heterogeneity (ITH) and clonal evolution playing a key role in tumor progression and metastases. Large-scale high-depth multiregional sequencing of colorectal cancer, comparative analysis among patients with right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer (RC), as well as the study of lymph node metastasis (LN) with extranodal tumor deposits (ENTDs) from evolutionary perspective remain weakly explored. Here, we recruited 68 patients with RCC (18), LCC (20), and RC (30). We performed high-depth whole-exome sequencing of 206 tumor regions including 176 primary tumors, 19 LN, and 11 ENTD samples. Our results showed ITH with a Darwinian pattern of evolution and the evolution pattern of LCC and RC was more complex and divergent than RCC. Genetic and evolutionary evidences found that both LN and ENTD originated from different clones. Moreover, ENTD was a distinct entity from LN and evolved later.

KW - Cancer Systems Biology

KW - Evolutionary Biology

KW - Genomics

UR - https://www.scopus.com/pages/publications/85108814067

U2 - 10.1016/j.isci.2021.102718

DO - 10.1016/j.isci.2021.102718

M3 - 文章

AN - SCOPUS:85108814067

SN - 2589-0042

VL - 24

JO - iScience

JF - iScience

IS - 7

M1 - 102718

ER -

Comparative analysis of clonal evolution among patients with right- and left-sided colon and rectal cancer

Abstract

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Keywords

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