TY - JOUR
T1 - Deep brain stimulation for epilepsy in clinical practice and in animal models
AU - Zhong, Xiao Ling
AU - Yu, Jin Tai
AU - Zhang, Qun
AU - Wang, Nai Dong
AU - Tan, Lan
PY - 2011/5/30
Y1 - 2011/5/30
N2 - Given the tremendous success of deep brain stimulation (DBS) for the treatment of movement and neuropsychiatric disorders, clinicians have begun to open up to the possible use of electrical stimulation for the treatment of patients with uncontrolled seizures. DBS of various neural targets has been investigated in clinical studies and animal studies, including the anterior nucleus of thalamus (ANT), cerebellum, hippocampus, subthalamic nucleus (STN), centromedian nucleus of the thalamus (CMT), caudate nucleus (CN). Recently, a large and multicenter trial (SANTE: Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy) was conducted and subsequently with encouraging results, making ANT the most well-established target for DBS in the treatment of epilepsy to date. Here, we endeavor to review mainly the animal studies and clinical studies of ANT DBS to further explore the more reliable target.
AB - Given the tremendous success of deep brain stimulation (DBS) for the treatment of movement and neuropsychiatric disorders, clinicians have begun to open up to the possible use of electrical stimulation for the treatment of patients with uncontrolled seizures. DBS of various neural targets has been investigated in clinical studies and animal studies, including the anterior nucleus of thalamus (ANT), cerebellum, hippocampus, subthalamic nucleus (STN), centromedian nucleus of the thalamus (CMT), caudate nucleus (CN). Recently, a large and multicenter trial (SANTE: Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy) was conducted and subsequently with encouraging results, making ANT the most well-established target for DBS in the treatment of epilepsy to date. Here, we endeavor to review mainly the animal studies and clinical studies of ANT DBS to further explore the more reliable target.
KW - Anterior nucleus of thalamus
KW - Deep brain stimulation
KW - Epilepsy
KW - Treatment
UR - https://www.scopus.com/pages/publications/79957817302
U2 - 10.1016/j.brainresbull.2011.03.020
DO - 10.1016/j.brainresbull.2011.03.020
M3 - 文献综述
C2 - 21457763
AN - SCOPUS:79957817302
SN - 0361-9230
VL - 85
SP - 81
EP - 88
JO - Brain Research Bulletin
JF - Brain Research Bulletin
IS - 3-4
ER -