Developments in ghrelin biology and potential clinical relevance

Roy G. Smith; Hong Jiang; Yuxiang Sun

doi:10.1016/j.tem.2005.09.004

Developments in ghrelin biology and potential clinical relevance

Roy G. Smith
, Hong Jiang
, Yuxiang Sun

Baylor College of Medicine

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

Abstract

The spiropiperidine, MK0677, has been exploited to characterize and expression clone the growth hormone secretagogue receptor (GHS-R). Cloning of this receptor led to identification of its natural ligands, ghrelin and adenosine. Targeted disruption of the Ghsr gene demonstrated unambiguously that the GH-releasing and orexigenic properties of ghrelin are dependent on Ghsr expression and that the orexigenic signal is mediated through neuropeptide Y and agouti-related peptide neurons. This review summarizes new developments in our understanding of the physiological roles of ghrelin and its receptor (GHS-R). Recent discoveries of the effects of ghrelin on the thymus and proinflammatory and chemotactic cytokine pathways stimulate renewed interest in potential clinical applications, which include age-associated disorders, such as metabolic disease, sarcopenia, congestive heart failure, atherosclerosis and anorexia.

Original language	English
Pages (from-to)	436-442
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	16
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2005.09.004
State	Published - Nov 2005
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.tem.2005.09.004

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title = "Developments in ghrelin biology and potential clinical relevance",

abstract = "The spiropiperidine, MK0677, has been exploited to characterize and expression clone the growth hormone secretagogue receptor (GHS-R). Cloning of this receptor led to identification of its natural ligands, ghrelin and adenosine. Targeted disruption of the Ghsr gene demonstrated unambiguously that the GH-releasing and orexigenic properties of ghrelin are dependent on Ghsr expression and that the orexigenic signal is mediated through neuropeptide Y and agouti-related peptide neurons. This review summarizes new developments in our understanding of the physiological roles of ghrelin and its receptor (GHS-R). Recent discoveries of the effects of ghrelin on the thymus and proinflammatory and chemotactic cytokine pathways stimulate renewed interest in potential clinical applications, which include age-associated disorders, such as metabolic disease, sarcopenia, congestive heart failure, atherosclerosis and anorexia.",

author = "Smith, \{Roy G.\} and Hong Jiang and Yuxiang Sun",

year = "2005",

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doi = "10.1016/j.tem.2005.09.004",

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TY - JOUR

T1 - Developments in ghrelin biology and potential clinical relevance

AU - Smith, Roy G.

AU - Jiang, Hong

AU - Sun, Yuxiang

PY - 2005/11

Y1 - 2005/11

N2 - The spiropiperidine, MK0677, has been exploited to characterize and expression clone the growth hormone secretagogue receptor (GHS-R). Cloning of this receptor led to identification of its natural ligands, ghrelin and adenosine. Targeted disruption of the Ghsr gene demonstrated unambiguously that the GH-releasing and orexigenic properties of ghrelin are dependent on Ghsr expression and that the orexigenic signal is mediated through neuropeptide Y and agouti-related peptide neurons. This review summarizes new developments in our understanding of the physiological roles of ghrelin and its receptor (GHS-R). Recent discoveries of the effects of ghrelin on the thymus and proinflammatory and chemotactic cytokine pathways stimulate renewed interest in potential clinical applications, which include age-associated disorders, such as metabolic disease, sarcopenia, congestive heart failure, atherosclerosis and anorexia.

AB - The spiropiperidine, MK0677, has been exploited to characterize and expression clone the growth hormone secretagogue receptor (GHS-R). Cloning of this receptor led to identification of its natural ligands, ghrelin and adenosine. Targeted disruption of the Ghsr gene demonstrated unambiguously that the GH-releasing and orexigenic properties of ghrelin are dependent on Ghsr expression and that the orexigenic signal is mediated through neuropeptide Y and agouti-related peptide neurons. This review summarizes new developments in our understanding of the physiological roles of ghrelin and its receptor (GHS-R). Recent discoveries of the effects of ghrelin on the thymus and proinflammatory and chemotactic cytokine pathways stimulate renewed interest in potential clinical applications, which include age-associated disorders, such as metabolic disease, sarcopenia, congestive heart failure, atherosclerosis and anorexia.

UR - https://www.scopus.com/pages/publications/27144468685

U2 - 10.1016/j.tem.2005.09.004

DO - 10.1016/j.tem.2005.09.004

M3 - 文献综述

C2 - 16213742

AN - SCOPUS:27144468685

SN - 1043-2760

VL - 16

SP - 436

EP - 442

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 9

ER -

Developments in ghrelin biology and potential clinical relevance

Abstract

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