Effects of deubiquitylases on the biological behaviors of neural stem cells

Qiqi Zhao; Yixin Li; Xixun Du; Xi Chen; Qian Jiao; Hong Jiang

doi:10.1002/dneu.22844

Effects of deubiquitylases on the biological behaviors of neural stem cells

Qiqi Zhao
, Yixin Li
, Xixun Du
, Xi Chen
, Qian Jiao
, Hong Jiang

Qingdao University

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an important factor in regulating neurogenesis. Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. Recent studies have provided growing evidence that deubiquitylases (DUBs) which reverse ubiquitylation process play critical roles in NSCs maintenance, differentiation and maturation. This review mainly focused on the relationship of DUBs and NSCs, and further summarized recent advances in our understanding of DUBs on regulating NSCs biological behaviors.

Original language	English
Pages (from-to)	847-858
Number of pages	12
Journal	Developmental Neurobiology
Volume	81
Issue number	6
DOIs	https://doi.org/10.1002/dneu.22844
State	Published - Sep 2021
Externally published	Yes

Keywords

deubiquitylases
neural stem cells
neurogenesis
transcription factors
ubiquitylation

Access to Document

10.1002/dneu.22844

Cite this

@article{c5ecc555e00f48be9ef98f1fd087b55e,

title = "Effects of deubiquitylases on the biological behaviors of neural stem cells",

abstract = "New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an important factor in regulating neurogenesis. Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. Recent studies have provided growing evidence that deubiquitylases (DUBs) which reverse ubiquitylation process play critical roles in NSCs maintenance, differentiation and maturation. This review mainly focused on the relationship of DUBs and NSCs, and further summarized recent advances in our understanding of DUBs on regulating NSCs biological behaviors.",

keywords = "deubiquitylases, neural stem cells, neurogenesis, transcription factors, ubiquitylation",

author = "Qiqi Zhao and Yixin Li and Xixun Du and Xi Chen and Qian Jiao and Hong Jiang",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = sep,

doi = "10.1002/dneu.22844",

language = "英语",

volume = "81",

pages = "847--858",

journal = "Developmental Neurobiology",

issn = "1932-8451",

publisher = "John Wiley \& Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Effects of deubiquitylases on the biological behaviors of neural stem cells

AU - Zhao, Qiqi

AU - Li, Yixin

AU - Du, Xixun

AU - Chen, Xi

AU - Jiao, Qian

AU - Jiang, Hong

PY - 2021/9

Y1 - 2021/9

N2 - New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an important factor in regulating neurogenesis. Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. Recent studies have provided growing evidence that deubiquitylases (DUBs) which reverse ubiquitylation process play critical roles in NSCs maintenance, differentiation and maturation. This review mainly focused on the relationship of DUBs and NSCs, and further summarized recent advances in our understanding of DUBs on regulating NSCs biological behaviors.

AB - New neurons are generated throughout life in distinct regions of the mammalian brain due to the proliferation and differentiation of neural stem cells (NSCs). Ubiquitin, a post-translational modification of cellular proteins, is an important factor in regulating neurogenesis. Deubiquitination is a biochemical process that mediates the removal of ubiquitin moieties from ubiquitin-conjugated substrates. Recent studies have provided growing evidence that deubiquitylases (DUBs) which reverse ubiquitylation process play critical roles in NSCs maintenance, differentiation and maturation. This review mainly focused on the relationship of DUBs and NSCs, and further summarized recent advances in our understanding of DUBs on regulating NSCs biological behaviors.

KW - deubiquitylases

KW - neural stem cells

KW - neurogenesis

KW - transcription factors

KW - ubiquitylation

UR - https://www.scopus.com/pages/publications/85111628938

U2 - 10.1002/dneu.22844

DO - 10.1002/dneu.22844

M3 - 文献综述

C2 - 34241974

AN - SCOPUS:85111628938

SN - 1932-8451

VL - 81

SP - 847

EP - 858

JO - Developmental Neurobiology

JF - Developmental Neurobiology

IS - 6

ER -

Effects of deubiquitylases on the biological behaviors of neural stem cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this