TY - JOUR
T1 - Effects of repetitive transcranial magnetic stimulation on neuropathic pain
T2 - A systematic review and meta-analysis
AU - Jiang, Xue
AU - Yan, Wangwang
AU - Wan, Ruihan
AU - Lin, Yangyang
AU - Zhu, Xiaoxia
AU - Song, Ge
AU - Zheng, Kangyong
AU - Wang, Yuling
AU - Wang, Xueqiang
N1 - Publisher Copyright:
© 2021
PY - 2022/1
Y1 - 2022/1
N2 - Neuropathic pain (NP) is a chronic pain condition caused by lesion or disease of the somatosensory nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a neuroregulatory tool that uses pulsed magnetic fields to modulate the cerebral cortex. This review aimed to ascertain the therapeutic effect of rTMS on NP and potential factors regulating the therapeutic effect of rTMS. Database search included Web of Science, Embase, Pubmed, and Cochrane Library from inception to July 2021. Eligible studies included randomized controlled studies of the analgesic effects of rTMS in patients with NP. Thirty-eight studies were included. Random effect analysis showed effect sizes of −0.66 (95 % CI, −0.87 to −0.46), indicating that real rTMS was better than sham condition in reducing pain (P < 0.001). This comprehensive review indicated that stimulation frequency, intervention site, and location of lesion were important factors affecting the therapeutic effect. The findings of this study may guide clinical decisions and future research.
AB - Neuropathic pain (NP) is a chronic pain condition caused by lesion or disease of the somatosensory nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a neuroregulatory tool that uses pulsed magnetic fields to modulate the cerebral cortex. This review aimed to ascertain the therapeutic effect of rTMS on NP and potential factors regulating the therapeutic effect of rTMS. Database search included Web of Science, Embase, Pubmed, and Cochrane Library from inception to July 2021. Eligible studies included randomized controlled studies of the analgesic effects of rTMS in patients with NP. Thirty-eight studies were included. Random effect analysis showed effect sizes of −0.66 (95 % CI, −0.87 to −0.46), indicating that real rTMS was better than sham condition in reducing pain (P < 0.001). This comprehensive review indicated that stimulation frequency, intervention site, and location of lesion were important factors affecting the therapeutic effect. The findings of this study may guide clinical decisions and future research.
KW - Meta-analysis
KW - Neuropathic pain
KW - Repetitive transcranial magnetic stimulation
KW - rTMS
UR - https://www.scopus.com/pages/publications/85120059791
U2 - 10.1016/j.neubiorev.2021.11.037
DO - 10.1016/j.neubiorev.2021.11.037
M3 - 文献综述
C2 - 34826512
AN - SCOPUS:85120059791
SN - 0149-7634
VL - 132
SP - 130
EP - 141
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -