GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABAB receptors in mouse hippocampus

Yingqian Liu; Xingwu Jordan Yang; Haiping Xia; Cha Min Tang; Kun Yang

doi:10.1016/j.bbrc.2019.10.044

GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABA_B receptors in mouse hippocampus

Yingqian Liu
, Xingwu Jordan Yang
, Haiping Xia
, Cha Min Tang
, Kun Yang

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Hippocampus CA1 pyramidal cells receive γ-aminobutyric acid (GABA) release from multiple GABAergic interneurons. Combining optogenetic strategy and whole-cell recordings, we demonstrate that baclofen, a specific GABA_B receptor agonist, depresses monosynaptic GABA_A receptor-mediated transmission from parvalbumin (PV)-expressing interneuron terminals onto pyramidal cells with less efficacy than that from the unspecific GABAergic terminals. The depression from PV neuron terminals is mainly mediated by presynaptic P/N type calcium channels. The results suggest that GABA_B receptors are widely expressed on GABAergic interneurons, where they exert inhibition onto pyramidal cells by GABA release with different efficacy. The data strengthen the proposal that diverse GABA neurons play different roles in modulating CA1 pyramidal cell excitability.

Original language	English
Pages (from-to)	449-452
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	520
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2019.10.044
State	Published - 3 Dec 2019
Externally published	Yes

Keywords

GABA
GABA receptors
Hippocampus
Optogenetics
Parvalbumin

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10.1016/j.bbrc.2019.10.044

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title = "GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABAB receptors in mouse hippocampus",

abstract = "Hippocampus CA1 pyramidal cells receive γ-aminobutyric acid (GABA) release from multiple GABAergic interneurons. Combining optogenetic strategy and whole-cell recordings, we demonstrate that baclofen, a specific GABAB receptor agonist, depresses monosynaptic GABAA receptor-mediated transmission from parvalbumin (PV)-expressing interneuron terminals onto pyramidal cells with less efficacy than that from the unspecific GABAergic terminals. The depression from PV neuron terminals is mainly mediated by presynaptic P/N type calcium channels. The results suggest that GABAB receptors are widely expressed on GABAergic interneurons, where they exert inhibition onto pyramidal cells by GABA release with different efficacy. The data strengthen the proposal that diverse GABA neurons play different roles in modulating CA1 pyramidal cell excitability.",

keywords = "GABA, GABA receptors, Hippocampus, Optogenetics, Parvalbumin",

author = "Yingqian Liu and Yang, \{Xingwu Jordan\} and Haiping Xia and Tang, \{Cha Min\} and Kun Yang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "3",

doi = "10.1016/j.bbrc.2019.10.044",

language = "英语",

volume = "520",

pages = "449--452",

journal = "Biochemical and Biophysical Research Communications",

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publisher = "Elsevier B.V.",

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GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABA_B receptors in mouse hippocampus. / Liu, Yingqian; Yang, Xingwu Jordan; Xia, Haiping et al.
In: Biochemical and Biophysical Research Communications, Vol. 520, No. 2, 03.12.2019, p. 449-452.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABAB receptors in mouse hippocampus

AU - Liu, Yingqian

AU - Yang, Xingwu Jordan

AU - Xia, Haiping

AU - Tang, Cha Min

AU - Yang, Kun

PY - 2019/12/3

Y1 - 2019/12/3

N2 - Hippocampus CA1 pyramidal cells receive γ-aminobutyric acid (GABA) release from multiple GABAergic interneurons. Combining optogenetic strategy and whole-cell recordings, we demonstrate that baclofen, a specific GABAB receptor agonist, depresses monosynaptic GABAA receptor-mediated transmission from parvalbumin (PV)-expressing interneuron terminals onto pyramidal cells with less efficacy than that from the unspecific GABAergic terminals. The depression from PV neuron terminals is mainly mediated by presynaptic P/N type calcium channels. The results suggest that GABAB receptors are widely expressed on GABAergic interneurons, where they exert inhibition onto pyramidal cells by GABA release with different efficacy. The data strengthen the proposal that diverse GABA neurons play different roles in modulating CA1 pyramidal cell excitability.

AB - Hippocampus CA1 pyramidal cells receive γ-aminobutyric acid (GABA) release from multiple GABAergic interneurons. Combining optogenetic strategy and whole-cell recordings, we demonstrate that baclofen, a specific GABAB receptor agonist, depresses monosynaptic GABAA receptor-mediated transmission from parvalbumin (PV)-expressing interneuron terminals onto pyramidal cells with less efficacy than that from the unspecific GABAergic terminals. The depression from PV neuron terminals is mainly mediated by presynaptic P/N type calcium channels. The results suggest that GABAB receptors are widely expressed on GABAergic interneurons, where they exert inhibition onto pyramidal cells by GABA release with different efficacy. The data strengthen the proposal that diverse GABA neurons play different roles in modulating CA1 pyramidal cell excitability.

KW - GABA

KW - GABA receptors

KW - Hippocampus

KW - Optogenetics

KW - Parvalbumin

UR - https://www.scopus.com/pages/publications/85073037866

U2 - 10.1016/j.bbrc.2019.10.044

DO - 10.1016/j.bbrc.2019.10.044

M3 - 文章

C2 - 31607482

AN - SCOPUS:85073037866

SN - 0006-291X

VL - 520

SP - 449

EP - 452

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

GABA releases from parvalbumin-expressing and unspecific GABAergic neurons onto CA1 pyramidal cells are differentially modulated by presynaptic GABA_B receptors in mouse hippocampus

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Keywords

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