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Identifying characteristic genes based on robust principal component analysis

  • Anhui University
  • Harbin Institute of Technology
  • Qufu Normal University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In this paper, based on robust PCA, a novel method of characteristic genes identification is proposed. In our method, the differentially expressed genes and non-differentially expressed genes are treated as perturbation signals S 0 and low-rank matrix A 0, respectively, which can be recovered from the gene expression data using robust PCA. The scheme to identify the characteristic genes is as following. Firstly, the matrix S 0 of perturbation signals is discovered from gene expression data matrix D by using robust PCA. Secondly, the characteristic genes are selected according to matrix S 0. Finally, the characteristic genes are checked by the tool of Gene Ontology. The experimental results show that our method is efficient and effective.

Original languageEnglish
Title of host publicationEmerging Intelligent Computing Technology and Applications - 8th International Conference, ICIC 2012, Proceedings
Pages174-179
Number of pages6
DOIs
StatePublished - 2012
Externally publishedYes
Event8th International Conference on Emerging Intelligent Computing Technology and Applications, ICIC 2012 - Huangshan, China
Duration: 25 Jul 201229 Jul 2012

Publication series

NameCommunications in Computer and Information Science
Volume304 CCIS
ISSN (Print)1865-0929

Conference

Conference8th International Conference on Emerging Intelligent Computing Technology and Applications, ICIC 2012
Country/TerritoryChina
CityHuangshan
Period25/07/1229/07/12

Keywords

  • gene expression data
  • gene identification
  • robust PCA

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