Abstract
Objective To determine the linkage between Smith-Fineman-Myers syndrome (SFMS) and X-linked nuclear protein (XNP) locus. Methods Polymerase chain reaction and denaturing polyacrylamide gel electrophoresis were used to genotype two polymorphic short tandem repeats within XNP gene. Results One of the two short tandem repeats was informative in SFMS family from Shandong, China. Recombination between SFMS locus and XNP gene was observed in the SFMS family. Conclusion XNP gene is not associated with the disease in the SFMS family from Shandong, China. SFMS exhibits locus heterogeneity at molecular level.
| Original language | English |
|---|---|
| Pages (from-to) | 22-25 |
| Number of pages | 4 |
| Journal | Chinese Journal of Medical Genetics |
| Volume | 19 |
| Issue number | 1 |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- Linkage analysis
- Smith-Fineman-Myers syndrome
- X-linked nuclear protein gene