Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians

Wanling Yang; Huayang Tang; Yan Zhang; Xianfa Tang; Jing Zhang; Liangdan Sun; Jing Yang; Yong Cui; Lu Zhang; Nattiya Hirankarn; Hui Cheng; Hai Feng Pan; Jinping Gao; Tsz Leung Lee; Yujun Sheng; Chak Sing Lau; Yang Li; Tak Mao Chan; Xianyong Yin; Dingge Ying; Qianjin Lu; Alexander Moon Ho Leung; Xianbo Zuo; Xiang Chen; Kwok Lung Tong; Fusheng Zhou; Qingchun Diao; Niko Kei Chiu Tse; Hongfu Xie; Chi Chiu Mok; Fei Hao; Sik Nin Wong; Bingjun Shi; Ka Wing Lee; Yan Hui; Marco Hok Kung Ho; Bo Liang; Pamela Pui Wah Lee; Hongzhou Cui; Qing Guo; Brian Hon Yin Chung; Xiongming Pu; Qiji Liu; Xiaoguang Zhang; Change Zhang; Chun Yin Chong; Hong Fang; Raymond Woon Sing Wong; Yonghu Sun; Mo Yin Mok; Xiang Pei Li; Yingyos Avihingsanon; Zhifang Zhai; Pornpimol Rianthavorn; Thavatchai Deekajorndej; Kanya Suphapeetiporn; Fei Gao; Vorasuk Shotelersuk; Xiaojing Kang; Shirley King Yee Ying; Lijuan Zhang; Wilfred Hing Sang Wong; Dingxian Zhu; Samuel Ka Shun Fung; Fanqin Zeng; Wai Ming Lai; Chun Ming Wong; Irene Oi Lin Ng; Maria Mercè Garcia-Barceló; Stacey S. Cherny; Nan Shen; Paul Kwong Hang Tam; Pak Chung Sham; Dong Qing Ye; Sen Yang; Xuejun Zhang; Yu Lung Lau

doi:10.1016/j.ajhg.2012.11.018

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians

Wanling Yang
, Huayang Tang
, Yan Zhang
, Xianfa Tang
, Jing Zhang
, Liangdan Sun
, Jing Yang
, Yong Cui
, Lu Zhang
, Nattiya Hirankarn
, Hui Cheng
, Hai Feng Pan
, Jinping Gao
, Tsz Leung Lee
, Yujun Sheng
, Chak Sing Lau
, Yang Li
, Tak Mao Chan
, Xianyong Yin
, Dingge Ying

Qianjin Lu, Alexander Moon Ho Leung, Xianbo Zuo, Xiang Chen, Kwok Lung Tong, Fusheng Zhou, Qingchun Diao, Niko Kei Chiu Tse, Hongfu Xie, Chi Chiu Mok, Fei Hao, Sik Nin Wong, Bingjun Shi, Ka Wing Lee, Yan Hui, Marco Hok Kung Ho, Bo Liang, Pamela Pui Wah Lee, Hongzhou Cui, Qing Guo, Brian Hon Yin Chung, Xiongming Pu, Qiji Liu, Xiaoguang Zhang, Change Zhang, Chun Yin Chong, Hong Fang, Raymond Woon Sing Wong, Yonghu Sun, Mo Yin Mok, Xiang Pei Li, Yingyos Avihingsanon, Zhifang Zhai, Pornpimol Rianthavorn, Thavatchai Deekajorndej, Kanya Suphapeetiporn, Fei Gao, Vorasuk Shotelersuk, Xiaojing Kang, Shirley King Yee Ying, Lijuan Zhang, Wilfred Hing Sang Wong, Dingxian Zhu, Samuel Ka Shun Fung, Fanqin Zeng, Wai Ming Lai, Chun Ming Wong, Irene Oi Lin Ng, Maria Mercè Garcia-Barceló, Stacey S. Cherny, Nan Shen, Paul Kwong Hang Tam, Pak Chung Sham, Dong Qing Ye, Sen Yang, Xuejun Zhang, Yu Lung Lau

The University of Hong Kong
Anhui Medical University
Chulalongkorn University
Central South University
Queen Elizabeth Hospital Hong Kong
Princess Margaret Hospital Hong Kong
First People's Hospital of Chongqing City
Tuen Mun Hospital
Third Military Medical University
Pamela Youde Nethersole Eastern Hospital
Xinjiang Medical University
Second Affiliated Hospital of SunYat-sen University
People's Hospital of Xinjiang Uygur Autonomous Region
Shandong University
Zhejiang University
Anhui Provincial Hospital
King Chulalongkorn Memorial Hospital
Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases.

Original language	English
Pages (from-to)	41-51
Number of pages	11
Journal	American Journal of Human Genetics
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/j.ajhg.2012.11.018
State	Published - 10 Jan 2013
Externally published	Yes

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10.1016/j.ajhg.2012.11.018

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Yang, W., Tang, H., Zhang, Y., Tang, X., Zhang, J., Sun, L., Yang, J., Cui, Y., Zhang, L., Hirankarn, N., Cheng, H., Pan, H. F., Gao, J., Lee, T. L., Sheng, Y., Lau, C. S., Li, Y., Chan, T. M., Yin, X., ... Lau, Y. L. (2013). Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. American Journal of Human Genetics, 92(1), 41-51. https://doi.org/10.1016/j.ajhg.2012.11.018

@article{c2931569517e4670bd8979e94dacfe66,

title = "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians",

abstract = "Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases.",

author = "Wanling Yang and Huayang Tang and Yan Zhang and Xianfa Tang and Jing Zhang and Liangdan Sun and Jing Yang and Yong Cui and Lu Zhang and Nattiya Hirankarn and Hui Cheng and Pan, \{Hai Feng\} and Jinping Gao and Lee, \{Tsz Leung\} and Yujun Sheng and Lau, \{Chak Sing\} and Yang Li and Chan, \{Tak Mao\} and Xianyong Yin and Dingge Ying and Qianjin Lu and Leung, \{Alexander Moon Ho\} and Xianbo Zuo and Xiang Chen and Tong, \{Kwok Lung\} and Fusheng Zhou and Qingchun Diao and Tse, \{Niko Kei Chiu\} and Hongfu Xie and Mok, \{Chi Chiu\} and Fei Hao and Wong, \{Sik Nin\} and Bingjun Shi and Lee, \{Ka Wing\} and Yan Hui and Ho, \{Marco Hok Kung\} and Bo Liang and Lee, \{Pamela Pui Wah\} and Hongzhou Cui and Qing Guo and Chung, \{Brian Hon Yin\} and Xiongming Pu and Qiji Liu and Xiaoguang Zhang and Change Zhang and Chong, \{Chun Yin\} and Hong Fang and Wong, \{Raymond Woon Sing\} and Yonghu Sun and Mok, \{Mo Yin\} and Li, \{Xiang Pei\} and Yingyos Avihingsanon and Zhifang Zhai and Pornpimol Rianthavorn and Thavatchai Deekajorndej and Kanya Suphapeetiporn and Fei Gao and Vorasuk Shotelersuk and Xiaojing Kang and Ying, \{Shirley King Yee\} and Lijuan Zhang and Wong, \{Wilfred Hing Sang\} and Dingxian Zhu and Fung, \{Samuel Ka Shun\} and Fanqin Zeng and Lai, \{Wai Ming\} and Wong, \{Chun Ming\} and Ng, \{Irene Oi Lin\} and Garcia-Barcel{\'o}, \{Maria Merc{\`e}\} and Cherny, \{Stacey S.\} and Nan Shen and Tam, \{Paul Kwong Hang\} and Sham, \{Pak Chung\} and Ye, \{Dong Qing\} and Sen Yang and Xuejun Zhang and Lau, \{Yu Lung\}",

year = "2013",

month = jan,

day = "10",

doi = "10.1016/j.ajhg.2012.11.018",

language = "英语",

volume = "92",

pages = "41--51",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "1",

}

Yang, W, Tang, H, Zhang, Y, Tang, X, Zhang, J, Sun, L, Yang, J, Cui, Y, Zhang, L, Hirankarn, N, Cheng, H, Pan, HF, Gao, J, Lee, TL, Sheng, Y, Lau, CS, Li, Y, Chan, TM, Yin, X, Ying, D, Lu, Q, Leung, AMH, Zuo, X, Chen, X, Tong, KL, Zhou, F, Diao, Q, Tse, NKC, Xie, H, Mok, CC, Hao, F, Wong, SN, Shi, B, Lee, KW, Hui, Y, Ho, MHK, Liang, B, Lee, PPW, Cui, H, Guo, Q, Chung, BHY, Pu, X, Liu, Q, Zhang, X, Zhang, C, Chong, CY, Fang, H, Wong, RWS, Sun, Y, Mok, MY, Li, XP, Avihingsanon, Y, Zhai, Z, Rianthavorn, P, Deekajorndej, T, Suphapeetiporn, K, Gao, F, Shotelersuk, V, Kang, X, Ying, SKY, Zhang, L, Wong, WHS, Zhu, D, Fung, SKS, Zeng, F, Lai, WM, Wong, CM, Ng, IOL, Garcia-Barceló, MM, Cherny, SS, Shen, N, Tam, PKH, Sham, PC, Ye, DQ, Yang, S, Zhang, X & Lau, YL 2013, 'Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians', American Journal of Human Genetics, vol. 92, no. 1, pp. 41-51. https://doi.org/10.1016/j.ajhg.2012.11.018

TY - JOUR

T1 - Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians

AU - Yang, Wanling

AU - Tang, Huayang

AU - Zhang, Yan

AU - Tang, Xianfa

AU - Zhang, Jing

AU - Sun, Liangdan

AU - Yang, Jing

AU - Cui, Yong

AU - Zhang, Lu

AU - Hirankarn, Nattiya

AU - Cheng, Hui

AU - Pan, Hai Feng

AU - Gao, Jinping

AU - Lee, Tsz Leung

AU - Sheng, Yujun

AU - Lau, Chak Sing

AU - Li, Yang

AU - Chan, Tak Mao

AU - Yin, Xianyong

AU - Ying, Dingge

AU - Lu, Qianjin

AU - Leung, Alexander Moon Ho

AU - Zuo, Xianbo

AU - Chen, Xiang

AU - Tong, Kwok Lung

AU - Zhou, Fusheng

AU - Diao, Qingchun

AU - Tse, Niko Kei Chiu

AU - Xie, Hongfu

AU - Mok, Chi Chiu

AU - Hao, Fei

AU - Wong, Sik Nin

AU - Shi, Bingjun

AU - Lee, Ka Wing

AU - Hui, Yan

AU - Ho, Marco Hok Kung

AU - Liang, Bo

AU - Lee, Pamela Pui Wah

AU - Cui, Hongzhou

AU - Guo, Qing

AU - Chung, Brian Hon Yin

AU - Pu, Xiongming

AU - Liu, Qiji

AU - Zhang, Xiaoguang

AU - Zhang, Change

AU - Chong, Chun Yin

AU - Fang, Hong

AU - Wong, Raymond Woon Sing

AU - Sun, Yonghu

AU - Mok, Mo Yin

AU - Li, Xiang Pei

AU - Avihingsanon, Yingyos

AU - Zhai, Zhifang

AU - Rianthavorn, Pornpimol

AU - Deekajorndej, Thavatchai

AU - Suphapeetiporn, Kanya

AU - Gao, Fei

AU - Shotelersuk, Vorasuk

AU - Kang, Xiaojing

AU - Ying, Shirley King Yee

AU - Zhang, Lijuan

AU - Wong, Wilfred Hing Sang

AU - Zhu, Dingxian

AU - Fung, Samuel Ka Shun

AU - Zeng, Fanqin

AU - Lai, Wai Ming

AU - Wong, Chun Ming

AU - Ng, Irene Oi Lin

AU - Garcia-Barceló, Maria Mercè

AU - Cherny, Stacey S.

AU - Shen, Nan

AU - Tam, Paul Kwong Hang

AU - Sham, Pak Chung

AU - Ye, Dong Qing

AU - Yang, Sen

AU - Zhang, Xuejun

AU - Lau, Yu Lung

PY - 2013/1/10

Y1 - 2013/1/10

N2 - Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases.

AB - Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases.

UR - https://www.scopus.com/pages/publications/84872328824

U2 - 10.1016/j.ajhg.2012.11.018

DO - 10.1016/j.ajhg.2012.11.018

M3 - 文章

C2 - 23273568

AN - SCOPUS:84872328824

SN - 0002-9297

VL - 92

SP - 41

EP - 51

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 1

ER -

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians

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