Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: The protective effects of pomegranate with its active component punicalagin

  • Xuan Zou
  • , Chunhong Yan
  • , Yujie Shi
  • , Ke Cao
  • , Jie Xu
  • , Xun Wang
  • , Cong Chen
  • , Cheng Luo
  • , Yuan Li
  • , Jing Gao
  • , Wentao Pang
  • , Jialong Zhao
  • , Fei Zhao
  • , Hao Li
  • , Adi Zheng
  • , Wenyan Sun
  • , Jiangang Long
  • , Ignatius Man Yau Szeto
  • , Youyou Zhao
  • , Zhizhong Dong
  • Peifang Zhang, Junkuan Wang, Wuyuan Lu, Yong Zhang, Jiankang Liu, Zhihui Feng

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Aims: Punicalagin (PU) is one of the major ellagitannins found in the pomegranate (Punica granatum), which is a popular fruit with several health benefits. So far, no studies have evaluated the effects of PU on nonalcoholic fatty liver disease (NAFLD). Our work aims at studying the effect of PU-enriched pomegranate extract (PE) on high fat diet (HFD)-induced NAFLD.

Original languageEnglish
Pages (from-to)1557-1570
Number of pages14
JournalAntioxidants and Redox Signaling
Volume21
Issue number11
DOIs
StatePublished - 10 Oct 2014
Externally publishedYes

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