Mn(ii)-Catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases

Jinfei Yang; Xiaolong Wu; Banghua Yang; Yirong Liu; Rui Cheng; Zijun Gong; Fei Sun

doi:10.1039/d0ra10172a

Mn(ii)-Catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases

Jinfei Yang
, Xiaolong Wu
, Banghua Yang
, Yirong Liu
, Rui Cheng
, Zijun Gong
, Fei Sun

School of Medicine of Nantong University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A Mn(ii)-catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl₂was critical for theortho-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds3mon 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg⁻¹3mafter two weeks, while treatment with 10 mg kg⁻¹3mled to obvious sperm production. Notably, if we increase the dose to 100 mg kg⁻¹, there will be a lot of sperm production in the epididymis and testes after two weeks of treatment. The results of this study will be of great significance in research on drugs for treating azoospermia and oligospermia diseases.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	RSC Advances
Volume	11
Issue number	1
DOIs	https://doi.org/10.1039/d0ra10172a
State	Published - 7 Dec 2020
Externally published	Yes

Access to Document

10.1039/d0ra10172a

Cite this

@article{76a3e2de6cd442a7b17f6bb4657f44fd,

title = "Mn(ii)-Catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases",

abstract = "A Mn(ii)-catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl2was critical for theortho-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds3mon 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg−13mafter two weeks, while treatment with 10 mg kg−13mled to obvious sperm production. Notably, if we increase the dose to 100 mg kg−1, there will be a lot of sperm production in the epididymis and testes after two weeks of treatment. The results of this study will be of great significance in research on drugs for treating azoospermia and oligospermia diseases.",

author = "Jinfei Yang and Xiaolong Wu and Banghua Yang and Yirong Liu and Rui Cheng and Zijun Gong and Fei Sun",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2020.",

year = "2020",

month = dec,

day = "7",

doi = "10.1039/d0ra10172a",

language = "英语",

volume = "11",

pages = "164--167",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Mn(ii)-Catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases

AU - Yang, Jinfei

AU - Wu, Xiaolong

AU - Yang, Banghua

AU - Liu, Yirong

AU - Cheng, Rui

AU - Gong, Zijun

AU - Sun, Fei

PY - 2020/12/7

Y1 - 2020/12/7

N2 - A Mn(ii)-catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl2was critical for theortho-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds3mon 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg−13mafter two weeks, while treatment with 10 mg kg−13mled to obvious sperm production. Notably, if we increase the dose to 100 mg kg−1, there will be a lot of sperm production in the epididymis and testes after two weeks of treatment. The results of this study will be of great significance in research on drugs for treating azoospermia and oligospermia diseases.

AB - A Mn(ii)-catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases were developed. The use of MnCl2was critical for theortho-alkenylation of aromatic amines. The general applicability of this procedure was highlighted by the synthesis of 27 vinylanilines, with good regioselectivities. The value of our approach in practical applications was investigated by studying the effects of one of the compounds3mon 8 week-old adult male rats with azoospermia as a mammalian model. The results show that a small amount of sperm will gradually be produced in the epididymis and testes by treatment of 8 week-old adult male rats with azoospermia with 1 mg kg−13mafter two weeks, while treatment with 10 mg kg−13mled to obvious sperm production. Notably, if we increase the dose to 100 mg kg−1, there will be a lot of sperm production in the epididymis and testes after two weeks of treatment. The results of this study will be of great significance in research on drugs for treating azoospermia and oligospermia diseases.

UR - https://www.scopus.com/pages/publications/85100380548

U2 - 10.1039/d0ra10172a

DO - 10.1039/d0ra10172a

M3 - 文章

AN - SCOPUS:85100380548

SN - 2046-2069

VL - 11

SP - 164

EP - 167

JO - RSC Advances

JF - RSC Advances

IS - 1

ER -

Mn(ii)-Catalysedortho-alkenylation of aromatic amines and its application in reproductive diseases

Abstract

Access to Document

Other files and links

Fingerprint

Cite this