Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

Caifeng Shao; Pei Chen; Qian Chen; Mingwei Zhao; Wei Ning Zhang; Kun Yang

doi:10.1016/j.bbrc.2019.12.013

Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

Caifeng Shao
, Pei Chen
, Qian Chen
, Mingwei Zhao
, Wei Ning Zhang
, Kun Yang

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.

Original language	English
Pages (from-to)	1059-1062
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	522
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2019.12.013
State	Published - 19 Feb 2020
Externally published	Yes

Keywords

GABA
Hippocampus
Mu opioid receptors
Optogenetics
Parvalbumin
Whole-cell recordings

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10.1016/j.bbrc.2019.12.013

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title = "Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells",

abstract = "Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.",

keywords = "GABA, Hippocampus, Mu opioid receptors, Optogenetics, Parvalbumin, Whole-cell recordings",

author = "Caifeng Shao and Pei Chen and Qian Chen and Mingwei Zhao and Zhang, \{Wei Ning\} and Kun Yang",

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year = "2020",

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doi = "10.1016/j.bbrc.2019.12.013",

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T1 - Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

AU - Shao, Caifeng

AU - Chen, Pei

AU - Chen, Qian

AU - Zhao, Mingwei

AU - Zhang, Wei Ning

AU - Yang, Kun

PY - 2020/2/19

Y1 - 2020/2/19

N2 - Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.

AB - Selectively activating (by optogenetics) parvalbumin-expressing (PV) interneurons induces GABA release onto CA1 pyramidal cells. Here we report that this release was attenuated by presynaptic mu opioid receptors (MORs) activation. On the other hand, conventional electric shock, presumably activating non-selectively presynaptic GABAergic terminals, also induced GABA release; however, this release showed relatively limited depression by MORs activation. The data suggest that MORs specifically inhibit GABA release from PV terminals and therefore, further support the idea that MORs contribute to homeostasis in CA1 neuro-circuit.

KW - GABA

KW - Hippocampus

KW - Mu opioid receptors

KW - Optogenetics

KW - Parvalbumin

KW - Whole-cell recordings

UR - https://www.scopus.com/pages/publications/85076249365

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DO - 10.1016/j.bbrc.2019.12.013

M3 - 文章

C2 - 31818459

AN - SCOPUS:85076249365

SN - 0006-291X

VL - 522

SP - 1059

EP - 1062

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Mu opioid receptors inhibit GABA release from parvalbumin interneuron terminals onto CA1 pyramidal cells

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