TY - JOUR
T1 - Non-invasive Modulation of Deep Brain Nuclei by Temporal Interference Stimulation
AU - Li, Long
AU - Bai, Hao
AU - Wu, Linyan
AU - Zheng, Liang
AU - Huang, Liang
AU - Li, Yang
AU - Zhang, Wenlong
AU - Wang, Jue
AU - Ge, Shunnan
AU - Qu, Yan
AU - Liu, Tian
N1 - Publisher Copyright:
© Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 2025.
PY - 2025/5
Y1 - 2025/5
N2 - Temporal interference (TI) is a form of stimulation that epitomizes an innovative and non-invasive approach for profound neuromodulation of the brain, a technique that has been validated in mice. Yet, the thin cranial bone structure of mice has a marginal influence on the effect of the TI technique and may not effectively showcase its effectiveness in larger animals. Based on this, we carried out TI stimulation experiments on rats. Following the TI intervention, analysis of electrophysiological data and immunofluorescence staining indicated the generation of a stimulation focus within the nucleus accumbens (depth, 8.5 mm) in rats. Our findings affirm the viability of the TI methodology in the presence of thick cranial bones, furnishing efficacious parameters for profound stimulation with TI administered under such conditions. This experiment not only sheds light on the intervention effects of TI deep in the brain but also furnishes robust evidence in support of its prospective clinical utility.
AB - Temporal interference (TI) is a form of stimulation that epitomizes an innovative and non-invasive approach for profound neuromodulation of the brain, a technique that has been validated in mice. Yet, the thin cranial bone structure of mice has a marginal influence on the effect of the TI technique and may not effectively showcase its effectiveness in larger animals. Based on this, we carried out TI stimulation experiments on rats. Following the TI intervention, analysis of electrophysiological data and immunofluorescence staining indicated the generation of a stimulation focus within the nucleus accumbens (depth, 8.5 mm) in rats. Our findings affirm the viability of the TI methodology in the presence of thick cranial bones, furnishing efficacious parameters for profound stimulation with TI administered under such conditions. This experiment not only sheds light on the intervention effects of TI deep in the brain but also furnishes robust evidence in support of its prospective clinical utility.
KW - Finite element simulation
KW - Local field potentials
KW - Noninvasive brain stimulation
KW - Temporal interference
KW - c-Fos
UR - https://www.scopus.com/pages/publications/85217748072
U2 - 10.1007/s12264-025-01359-7
DO - 10.1007/s12264-025-01359-7
M3 - 文章
C2 - 39920435
AN - SCOPUS:85217748072
SN - 1673-7067
VL - 41
SP - 853
EP - 865
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
IS - 5
ER -