ORMDL3 and its implication in inflammatory disorders

Xiaochun Ma; Feng Long; Yan Yun; Jie Dang; Shijun Wei; Qian Zhang; Jinzhang Li; Haizhou Zhang; Wenlong Zhang; Zhengjun Wang; Qiji Liu; Chengwei Zou

doi:10.1111/1756-185X.13324

ORMDL3 and its implication in inflammatory disorders

Xiaochun Ma
, Feng Long
, Yan Yun
, Jie Dang
, Shijun Wei
, Qian Zhang
, Jinzhang Li
, Haizhou Zhang
, Wenlong Zhang
, Zhengjun Wang
, Qiji Liu
, Chengwei Zou

Shandong First Medical University & Shandong Academy of Medical Sciences
Shandong University
Qilu Hospital of Shandong University
Ningxia Medical University

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini-review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.

Original language	English
Pages (from-to)	1154-1162
Number of pages	9
Journal	International Journal of Rheumatic Diseases
Volume	21
Issue number	6
DOIs	https://doi.org/10.1111/1756-185X.13324
State	Published - Jun 2018
Externally published	Yes

Keywords

ORMDL3
apoptosis
autophagy
endoplasmic reticulum stress
inflammation
lipid metabolism
polymorphism

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10.1111/1756-185X.13324

Cite this

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title = "ORMDL3 and its implication in inflammatory disorders",

abstract = "A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini-review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.",

keywords = "ORMDL3, apoptosis, autophagy, endoplasmic reticulum stress, inflammation, lipid metabolism, polymorphism",

author = "Xiaochun Ma and Feng Long and Yan Yun and Jie Dang and Shijun Wei and Qian Zhang and Jinzhang Li and Haizhou Zhang and Wenlong Zhang and Zhengjun Wang and Qiji Liu and Chengwei Zou",

note = "Publisher Copyright: {\textcopyright} 2018 Asia Pacific League of Associations for Rheumatology and John Wiley \& Sons Australia, Ltd",

year = "2018",

month = jun,

doi = "10.1111/1756-185X.13324",

language = "英语",

volume = "21",

pages = "1154--1162",

journal = "International Journal of Rheumatic Diseases",

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}

TY - JOUR

T1 - ORMDL3 and its implication in inflammatory disorders

AU - Ma, Xiaochun

AU - Long, Feng

AU - Yun, Yan

AU - Dang, Jie

AU - Wei, Shijun

AU - Zhang, Qian

AU - Li, Jinzhang

AU - Zhang, Haizhou

AU - Zhang, Wenlong

AU - Wang, Zhengjun

AU - Liu, Qiji

AU - Zou, Chengwei

PY - 2018/6

Y1 - 2018/6

N2 - A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini-review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.

AB - A growing body of evidence has suggested the genetic association of ORMDL3 gene (ORMDL Sphingolipid Biosynthesis Regulator 3) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL3 gene expression in inflammation. This mini-review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL3 in common inflammatory disorders.

KW - ORMDL3

KW - apoptosis

KW - autophagy

KW - endoplasmic reticulum stress

KW - inflammation

KW - lipid metabolism

KW - polymorphism

UR - https://www.scopus.com/pages/publications/85048252429

U2 - 10.1111/1756-185X.13324

DO - 10.1111/1756-185X.13324

M3 - 文献综述

C2 - 29879314

AN - SCOPUS:85048252429

SN - 1756-1841

VL - 21

SP - 1154

EP - 1162

JO - International Journal of Rheumatic Diseases

JF - International Journal of Rheumatic Diseases

IS - 6

ER -

ORMDL3 and its implication in inflammatory disorders

Abstract

Keywords

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