TY - JOUR
T1 - Polysaccharides from Oudemansiella radicata residues attenuate carbon tetrachloride-induced liver injury
AU - Wang, Wenshuai
AU - Zhang, Yaohan
AU - Liu, Xinchao
AU - Liu, Zonghui
AU - Jia, Le
AU - Zhang, Jianjun
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/7/1
Y1 - 2023/7/1
N2 - The present work aimed to investigate the potential hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). Our results demonstrated that RPS showed significantly protective effects against carbon tetrachloride (CCl4)-induced liver injury, and the possible mechanisms may be related with the predominant bioactivities of RPS containing anti-oxidation by activating the Nrf2 signal pathways, anti-inflammation by inhibiting NF-κB signal pathways and reducing the release of inflammatory cytokines, anti-apoptosis by regulating Bcl-2/Bax pathway, and anti-fibrosis by inhibiting the expressions of TGF-β1, Hyp and α-SMA, respectively. These findings suggested that RPS, a typical β-type glycosidic pyranose, could be used as a promising diet supplement or medication for the adjunctive treatment of hepatic diseases, and also contributed to promoting the recyclable utilization of mushroom residues.
AB - The present work aimed to investigate the potential hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). Our results demonstrated that RPS showed significantly protective effects against carbon tetrachloride (CCl4)-induced liver injury, and the possible mechanisms may be related with the predominant bioactivities of RPS containing anti-oxidation by activating the Nrf2 signal pathways, anti-inflammation by inhibiting NF-κB signal pathways and reducing the release of inflammatory cytokines, anti-apoptosis by regulating Bcl-2/Bax pathway, and anti-fibrosis by inhibiting the expressions of TGF-β1, Hyp and α-SMA, respectively. These findings suggested that RPS, a typical β-type glycosidic pyranose, could be used as a promising diet supplement or medication for the adjunctive treatment of hepatic diseases, and also contributed to promoting the recyclable utilization of mushroom residues.
KW - Hepatoprotection
KW - Oudemansiella radicata
KW - Residue polysaccharides
UR - https://www.scopus.com/pages/publications/85162230571
U2 - 10.1016/j.ijbiomac.2023.124823
DO - 10.1016/j.ijbiomac.2023.124823
M3 - 文章
C2 - 37178886
AN - SCOPUS:85162230571
SN - 0141-8130
VL - 242
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 124823
ER -