Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae

Cheng Luo; Hui Wang; Xiaoxiao Chen; Yang Cui; Hua Li; Jiangang Long; Xiaoyan Mo; Jiankang Liu

doi:10.1016/j.phymed.2013.08.002

Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae

Cheng Luo
, Hui Wang
, Xiaoxiao Chen
, Yang Cui
, Hua Li
, Jiangang Long
, Xiaoyan Mo
, Jiankang Liu

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Total paeony glucosides (TPG) extracted from the roots of Radix Paeoniae Rubrae, have been approved for the therapy of rheumatoid arthritis by the State Food and Drug Administration. We previously demonstrated the myocardial protective effects of TPG in both isoprenaline-induced myocardial ischemia rat and acute myocardial infarction rat. However, the underlying mechanism of TPG effect in cardiomyocytes remains to be investigated. The aims of this study were to elucidate the effect of TPG on the activities of antioxidant defense targets and the bioenergetic system in rat cardiomyocytes. The changes of viability, antioxidant defense system activities, protein contents, and mitochondrial functions in tert-butyl hydroperoxide challenged H9c2 rat cardiomyoblasts were evaluated. The results suggest that TPG ameliorated cardiomyoblast dysfunction by preserving antioxidant defense and bioenergetic system.

Original language	English
Pages (from-to)	20-24
Number of pages	5
Journal	Phytomedicine
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.phymed.2013.08.002
State	Published - 15 Dec 2013
Externally published	Yes

Keywords

Cell death
Mitochondria
Phase II enzymes
Reactive oxygen species
Tert-butyl hydroperoxide
Total paeony glucosides

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10.1016/j.phymed.2013.08.002

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title = "Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae",

abstract = "Total paeony glucosides (TPG) extracted from the roots of Radix Paeoniae Rubrae, have been approved for the therapy of rheumatoid arthritis by the State Food and Drug Administration. We previously demonstrated the myocardial protective effects of TPG in both isoprenaline-induced myocardial ischemia rat and acute myocardial infarction rat. However, the underlying mechanism of TPG effect in cardiomyocytes remains to be investigated. The aims of this study were to elucidate the effect of TPG on the activities of antioxidant defense targets and the bioenergetic system in rat cardiomyocytes. The changes of viability, antioxidant defense system activities, protein contents, and mitochondrial functions in tert-butyl hydroperoxide challenged H9c2 rat cardiomyoblasts were evaluated. The results suggest that TPG ameliorated cardiomyoblast dysfunction by preserving antioxidant defense and bioenergetic system.",

keywords = "Cell death, Mitochondria, Phase II enzymes, Reactive oxygen species, Tert-butyl hydroperoxide, Total paeony glucosides",

author = "Cheng Luo and Hui Wang and Xiaoxiao Chen and Yang Cui and Hua Li and Jiangang Long and Xiaoyan Mo and Jiankang Liu",

year = "2013",

month = dec,

day = "15",

doi = "10.1016/j.phymed.2013.08.002",

language = "英语",

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journal = "Phytomedicine",

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T1 - Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae

AU - Luo, Cheng

AU - Wang, Hui

AU - Chen, Xiaoxiao

AU - Cui, Yang

AU - Li, Hua

AU - Long, Jiangang

AU - Mo, Xiaoyan

AU - Liu, Jiankang

PY - 2013/12/15

Y1 - 2013/12/15

N2 - Total paeony glucosides (TPG) extracted from the roots of Radix Paeoniae Rubrae, have been approved for the therapy of rheumatoid arthritis by the State Food and Drug Administration. We previously demonstrated the myocardial protective effects of TPG in both isoprenaline-induced myocardial ischemia rat and acute myocardial infarction rat. However, the underlying mechanism of TPG effect in cardiomyocytes remains to be investigated. The aims of this study were to elucidate the effect of TPG on the activities of antioxidant defense targets and the bioenergetic system in rat cardiomyocytes. The changes of viability, antioxidant defense system activities, protein contents, and mitochondrial functions in tert-butyl hydroperoxide challenged H9c2 rat cardiomyoblasts were evaluated. The results suggest that TPG ameliorated cardiomyoblast dysfunction by preserving antioxidant defense and bioenergetic system.

AB - Total paeony glucosides (TPG) extracted from the roots of Radix Paeoniae Rubrae, have been approved for the therapy of rheumatoid arthritis by the State Food and Drug Administration. We previously demonstrated the myocardial protective effects of TPG in both isoprenaline-induced myocardial ischemia rat and acute myocardial infarction rat. However, the underlying mechanism of TPG effect in cardiomyocytes remains to be investigated. The aims of this study were to elucidate the effect of TPG on the activities of antioxidant defense targets and the bioenergetic system in rat cardiomyocytes. The changes of viability, antioxidant defense system activities, protein contents, and mitochondrial functions in tert-butyl hydroperoxide challenged H9c2 rat cardiomyoblasts were evaluated. The results suggest that TPG ameliorated cardiomyoblast dysfunction by preserving antioxidant defense and bioenergetic system.

KW - Cell death

KW - Mitochondria

KW - Phase II enzymes

KW - Reactive oxygen species

KW - Tert-butyl hydroperoxide

KW - Total paeony glucosides

UR - https://www.scopus.com/pages/publications/84888857504

U2 - 10.1016/j.phymed.2013.08.002

DO - 10.1016/j.phymed.2013.08.002

M3 - 文章

C2 - 24035226

AN - SCOPUS:84888857504

SN - 0944-7113

VL - 21

SP - 20

EP - 24

JO - Phytomedicine

JF - Phytomedicine

IS - 1

ER -

Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae

Abstract

Keywords

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