[Protective effect of NEP on Abeta-induced apoptosis in PC12 cells].

Ji Ping Zeng; Ling Ling Yang; Wei Fang Wu; Feng Kong; Xiao Yan Hu; Xing Cui

[Protective effect of NEP on Abeta-induced apoptosis in PC12 cells].

Ji Ping Zeng
, Ling Ling Yang
, Wei Fang Wu
, Feng Kong
, Xiao Yan Hu
, Xing Cui

Shandong University

Research output: Contribution to journal › Article › peer-review

Abstract

To identify the effect of NEP on Abeta -induced apoptosis in PC12 cells. PC12 cells that stably express NEP is generated and the effect of NEP on the process of apoptosis induced by Abeta is analyzed, including the viability of the cells, the production of LDH, ROS and ATP, the activity of Caspase-3. NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS. In the same time, the activity of caspase-3 descended (P < 0.05). But iNEP had not significant effect on cells apoptosis (P > 0.05). NEP has the protective effect on Abeta-induced apoptosis in PC12 cells.

Original language	English
Pages (from-to)	722-725
Number of pages	4
Journal	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Volume	25
Issue number	12
State	Published - Dec 2007
Externally published	Yes

Cite this

@article{ba60e40eda9e46b0837e5a3832570096,

title = "[Protective effect of NEP on Abeta-induced apoptosis in PC12 cells].",

abstract = "To identify the effect of NEP on Abeta -induced apoptosis in PC12 cells. PC12 cells that stably express NEP is generated and the effect of NEP on the process of apoptosis induced by Abeta is analyzed, including the viability of the cells, the production of LDH, ROS and ATP, the activity of Caspase-3. NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS. In the same time, the activity of caspase-3 descended (P < 0.05). But iNEP had not significant effect on cells apoptosis (P > 0.05). NEP has the protective effect on Abeta-induced apoptosis in PC12 cells.",

author = "Zeng, \{Ji Ping\} and Yang, \{Ling Ling\} and Wu, \{Wei Fang\} and Feng Kong and Hu, \{Xiao Yan\} and Xing Cui",

year = "2007",

month = dec,

language = "英语",

volume = "25",

pages = "722--725",

journal = "Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases",

issn = "1001-9391",

publisher = "Chinese Medical Journals Publishing House Co.Ltd",

number = "12",

}

[Protective effect of NEP on Abeta-induced apoptosis in PC12 cells]. / Zeng, Ji Ping; Yang, Ling Ling; Wu, Wei Fang et al.
In: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, Vol. 25, No. 12, 12.2007, p. 722-725.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - [Protective effect of NEP on Abeta-induced apoptosis in PC12 cells].

AU - Zeng, Ji Ping

AU - Yang, Ling Ling

AU - Wu, Wei Fang

AU - Kong, Feng

AU - Hu, Xiao Yan

AU - Cui, Xing

PY - 2007/12

Y1 - 2007/12

N2 - To identify the effect of NEP on Abeta -induced apoptosis in PC12 cells. PC12 cells that stably express NEP is generated and the effect of NEP on the process of apoptosis induced by Abeta is analyzed, including the viability of the cells, the production of LDH, ROS and ATP, the activity of Caspase-3. NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS. In the same time, the activity of caspase-3 descended (P < 0.05). But iNEP had not significant effect on cells apoptosis (P > 0.05). NEP has the protective effect on Abeta-induced apoptosis in PC12 cells.

AB - To identify the effect of NEP on Abeta -induced apoptosis in PC12 cells. PC12 cells that stably express NEP is generated and the effect of NEP on the process of apoptosis induced by Abeta is analyzed, including the viability of the cells, the production of LDH, ROS and ATP, the activity of Caspase-3. NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS. In the same time, the activity of caspase-3 descended (P < 0.05). But iNEP had not significant effect on cells apoptosis (P > 0.05). NEP has the protective effect on Abeta-induced apoptosis in PC12 cells.

UR - https://www.scopus.com/pages/publications/84879792423

M3 - 文章

C2 - 18230302

AN - SCOPUS:84879792423

SN - 1001-9391

VL - 25

SP - 722

EP - 725

JO - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

JF - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

IS - 12

ER -

[Protective effect of NEP on Abeta-induced apoptosis in PC12 cells].

Abstract

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