Protective effects of gypenosides on focal brain ischemia-reperfusion injury in rats

Xiao qing Cao; Xiu mei Zhang; Xin bing Wei; Li xiang Wang; Hui qing Liu

Protective effects of gypenosides on focal brain ischemia-reperfusion injury in rats

Xiao qing Cao
, Xiu mei Zhang
, Xin bing Wei
, Li xiang Wang
, Hui qing Liu

Shandong University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

OBJECTIVE: To investigate the neuroprotective effect of gypenosides and nimodipine on focal brain ischemia reperfusion injury in rats. METHODS: The NO Levels of cerebral subcellular organ and histological examination were measured with a model of reversible middle cerebral artery occlusion (MCAO) without craniectomy in rats. RESULTS: It was found that the level of NO was increased and the number of living pyramidal cells in CA₁ region of hippocampus were decreased and the number of living pyramidal cells in CA₁ region of hippocampus were decreased significantly in ischemia-reperfusion group compared with Sham. No level was decreased and the number of living pyramidal cells in CA₁ region of hippocampus was increased significantly in gypenosides-treated groups and nimodipine-treated group compared with ischemia-reperfusion group. CONCLUSION: The result suggested that the decrease of NO production by gypenosides and nimodipine may play a role in the amelioration of focal brain ischemia-reperfusion injury.

Original language	English
Pages (from-to)	499-502
Number of pages	4
Journal	Chinese Pharmaceutical Journal
Volume	37
Issue number	7
State	Published - 2002
Externally published	Yes

Keywords

Brain ischemia-reperfusion injury
Gypenoside
Middle cerebral artery occlusion
Nitric oxide

Cite this

@article{1681827e830b4a9691135f740f293e0b,

title = "Protective effects of gypenosides on focal brain ischemia-reperfusion injury in rats",

abstract = "OBJECTIVE: To investigate the neuroprotective effect of gypenosides and nimodipine on focal brain ischemia reperfusion injury in rats. METHODS: The NO Levels of cerebral subcellular organ and histological examination were measured with a model of reversible middle cerebral artery occlusion (MCAO) without craniectomy in rats. RESULTS: It was found that the level of NO was increased and the number of living pyramidal cells in CA1 region of hippocampus were decreased and the number of living pyramidal cells in CA1 region of hippocampus were decreased significantly in ischemia-reperfusion group compared with Sham. No level was decreased and the number of living pyramidal cells in CA1 region of hippocampus was increased significantly in gypenosides-treated groups and nimodipine-treated group compared with ischemia-reperfusion group. CONCLUSION: The result suggested that the decrease of NO production by gypenosides and nimodipine may play a role in the amelioration of focal brain ischemia-reperfusion injury.",

keywords = "Brain ischemia-reperfusion injury, Gypenoside, Middle cerebral artery occlusion, Nitric oxide",

author = "Cao, \{Xiao qing\} and Zhang, \{Xiu mei\} and Wei, \{Xin bing\} and Wang, \{Li xiang\} and Liu, \{Hui qing\}",

year = "2002",

language = "英语",

volume = "37",

pages = "499--502",

journal = "Chinese Pharmaceutical Journal",

issn = "1001-2494",

publisher = "Chinese Pharmaceutical Association",

number = "7",

}

TY - JOUR

T1 - Protective effects of gypenosides on focal brain ischemia-reperfusion injury in rats

AU - Cao, Xiao qing

AU - Zhang, Xiu mei

AU - Wei, Xin bing

AU - Wang, Li xiang

AU - Liu, Hui qing

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: To investigate the neuroprotective effect of gypenosides and nimodipine on focal brain ischemia reperfusion injury in rats. METHODS: The NO Levels of cerebral subcellular organ and histological examination were measured with a model of reversible middle cerebral artery occlusion (MCAO) without craniectomy in rats. RESULTS: It was found that the level of NO was increased and the number of living pyramidal cells in CA1 region of hippocampus were decreased and the number of living pyramidal cells in CA1 region of hippocampus were decreased significantly in ischemia-reperfusion group compared with Sham. No level was decreased and the number of living pyramidal cells in CA1 region of hippocampus was increased significantly in gypenosides-treated groups and nimodipine-treated group compared with ischemia-reperfusion group. CONCLUSION: The result suggested that the decrease of NO production by gypenosides and nimodipine may play a role in the amelioration of focal brain ischemia-reperfusion injury.

AB - OBJECTIVE: To investigate the neuroprotective effect of gypenosides and nimodipine on focal brain ischemia reperfusion injury in rats. METHODS: The NO Levels of cerebral subcellular organ and histological examination were measured with a model of reversible middle cerebral artery occlusion (MCAO) without craniectomy in rats. RESULTS: It was found that the level of NO was increased and the number of living pyramidal cells in CA1 region of hippocampus were decreased and the number of living pyramidal cells in CA1 region of hippocampus were decreased significantly in ischemia-reperfusion group compared with Sham. No level was decreased and the number of living pyramidal cells in CA1 region of hippocampus was increased significantly in gypenosides-treated groups and nimodipine-treated group compared with ischemia-reperfusion group. CONCLUSION: The result suggested that the decrease of NO production by gypenosides and nimodipine may play a role in the amelioration of focal brain ischemia-reperfusion injury.

KW - Brain ischemia-reperfusion injury

KW - Gypenoside

KW - Middle cerebral artery occlusion

KW - Nitric oxide

UR - https://www.scopus.com/pages/publications/0036345738

M3 - 文章

AN - SCOPUS:0036345738

SN - 1001-2494

VL - 37

SP - 499

EP - 502

JO - Chinese Pharmaceutical Journal

JF - Chinese Pharmaceutical Journal

IS - 7

ER -

Protective effects of gypenosides on focal brain ischemia-reperfusion injury in rats

Abstract

Keywords

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