Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

Yong Jie Wang; Ming Gang Liu; Jing Hua Wang; Wei Cao; Cheng Wu; Zi Yue Wang; Li Liu; Fan Yang; Zhi Hui Feng; Li Sun; Fuxing Zhang; Yi Shen; Yu Dong Zhou; Min Zhuo; Jian Hong Luo; Tian Le Xu; Xiang Yao Li

doi:10.1016/j.celrep.2020.108369

Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

Yong Jie Wang
, Ming Gang Liu
, Jing Hua Wang
, Wei Cao
, Cheng Wu
, Zi Yue Wang
, Li Liu
, Fan Yang
, Zhi Hui Feng
, Li Sun
, Fuxing Zhang
, Yi Shen
, Yu Dong Zhou
, Min Zhuo
, Jian Hong Luo
, Tian Le Xu
, Xiang Yao Li

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.

Original language	English
Article number	108369
Journal	Cell Reports
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2020.108369
State	Published - 10 Nov 2020
Externally published	Yes

Keywords

Casp3 and GluA1 interaction
GluA1 internalization
GluA2
LTD
caspase 3
hypersensitivity
neuropathic pain
non-apoptotic function
spontaneous pain
synaptic transmission

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10.1016/j.celrep.2020.108369

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Wang, Y. J., Liu, M. G., Wang, J. H., Cao, W., Wu, C., Wang, Z. Y., Liu, L., Yang, F., Feng, Z. H., Sun, L., Zhang, F., Shen, Y., Zhou, Y. D., Zhuo, M., Luo, J. H., Xu, T. L., & Li, X. Y. (2020). Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. Cell Reports, 33(6), Article 108369. https://doi.org/10.1016/j.celrep.2020.108369

@article{b77c6269ea0b441e8c703c48d39ac5e3,

title = "Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity",

abstract = "Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.",

keywords = "Casp3 and GluA1 interaction, GluA1 internalization, GluA2, LTD, caspase 3, hypersensitivity, neuropathic pain, non-apoptotic function, spontaneous pain, synaptic transmission",

author = "Wang, \{Yong Jie\} and Liu, \{Ming Gang\} and Wang, \{Jing Hua\} and Wei Cao and Cheng Wu and Wang, \{Zi Yue\} and Li Liu and Fan Yang and Feng, \{Zhi Hui\} and Li Sun and Fuxing Zhang and Yi Shen and Zhou, \{Yu Dong\} and Min Zhuo and Luo, \{Jian Hong\} and Xu, \{Tian Le\} and Li, \{Xiang Yao\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = nov,

day = "10",

doi = "10.1016/j.celrep.2020.108369",

language = "英语",

volume = "33",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier B.V.",

number = "6",

}

Wang, YJ, Liu, MG, Wang, JH, Cao, W, Wu, C, Wang, ZY, Liu, L, Yang, F, Feng, ZH, Sun, L, Zhang, F, Shen, Y, Zhou, YD, Zhuo, M, Luo, JH, Xu, TL & Li, XY 2020, 'Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity', Cell Reports, vol. 33, no. 6, 108369. https://doi.org/10.1016/j.celrep.2020.108369

TY - JOUR

T1 - Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

AU - Wang, Yong Jie

AU - Liu, Ming Gang

AU - Wang, Jing Hua

AU - Cao, Wei

AU - Wu, Cheng

AU - Wang, Zi Yue

AU - Liu, Li

AU - Yang, Fan

AU - Feng, Zhi Hui

AU - Sun, Li

AU - Zhang, Fuxing

AU - Shen, Yi

AU - Zhou, Yu Dong

AU - Zhuo, Min

AU - Luo, Jian Hong

AU - Xu, Tian Le

AU - Li, Xiang Yao

PY - 2020/11/10

Y1 - 2020/11/10

N2 - Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.

AB - Wang et al. find that peripheral nerve injury prevents LTD induction in the anterior cingulate cortex (ACC) due to the downregulation of Casp3. Disrupting the interaction between Casp3 and AMPAR subunits inhibits LTD induction and induces peripheral pain hypersensitivity. Restoration of cingulate LTD rescues peripheral pain hypersensitivity.

KW - Casp3 and GluA1 interaction

KW - GluA1 internalization

KW - GluA2

KW - LTD

KW - caspase 3

KW - hypersensitivity

KW - neuropathic pain

KW - non-apoptotic function

KW - spontaneous pain

KW - synaptic transmission

UR - https://www.scopus.com/pages/publications/85096082646

U2 - 10.1016/j.celrep.2020.108369

DO - 10.1016/j.celrep.2020.108369

M3 - 文章

C2 - 33176141

AN - SCOPUS:85096082646

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 6

M1 - 108369

ER -

Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

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Keywords

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