Robust Graph Regularized Extreme Learning Machine Auto Encoder and Its Application to Single-Cell Samples Classification

  • Liang Rui Ren
  • , Jin Xing Liu
  • , Ying Lian Gao
  • , Xiang Zhen Kong
  • , Chun Hou Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Combined with Auto Encoder (AE), Extreme Learning Machine Auto Encoder (ELM-AE) has attracted the interest of researchers in recent years. Considering the classification tasks of single-cell Ribonucleic Acid sequencing (scRNA-seq) data, in this paper, we propose a novel supervised learning method based on ELM-AE, which is named Robust Graph Regularized Extreme Learning Machine Auto Encoder (RGELMAE). The method introduces L2,1-norm minimization on loss function to improve the robustness, and combines with the manifold regularization framework to explore the internal local structure between data points. Finally, RGELMAE is applied to the classification tasks of scRNA-seq data. The experimental results indicate that our method can effectively extract the key information representing the original data, and improve the classification performance of ELM.

Original languageEnglish
Title of host publicationIntelligent Computing Theories and Application - 16th International Conference, ICIC 2020, Proceedings
EditorsDe-Shuang Huang, Kang-Hyun Jo
PublisherSpringer Science and Business Media Deutschland GmbH
Pages537-545
Number of pages9
ISBN (Print)9783030608019
DOIs
StatePublished - 2020
Externally publishedYes
Event16th International Conference on Intelligent Computing, ICIC 2020 - Bari , Italy
Duration: 2 Oct 20205 Oct 2020

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12464 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference16th International Conference on Intelligent Computing, ICIC 2020
Country/TerritoryItaly
CityBari
Period2/10/205/10/20

Keywords

  • Auto encoder
  • Extreme learning machine
  • L-norm
  • Manifold regularization
  • Single-cell RNA-seq
  • Supervised learning

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