Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

Qingye Meng; Shuangling Zhong; Jingfei Wang; Zhenqian Zhang; Yan Gao; Xuejun Cui

doi:10.1016/j.partic.2023.06.006

Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

Qingye Meng
, Shuangling Zhong
, Jingfei Wang
, Zhenqian Zhang
, Yan Gao
, Xuejun Cui

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In this study, sodium alginate (SA), a non-toxic natural polysaccharide with good biocompatibility and biodegradability, was developed for targeted delivery of curcumin (CUR) in tumor therapy. The strategy is to sulfhydrylate the folic acid (FA) modified SA, and the CUR dissolved in ethyl acetate (EAC) phase is coated in microcapsules by a quick, efficient and environment-friendly sonochemical method. The EAC in the microcapsule core is volatile, which can be recycled and reused to reduce cost. The prepared microcapsules (FA-RSMCs@CUR) exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro. FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro. It is expected to become a low-cost tumor targeting vector in the future, and has the potential to be promoted in clinical application.

Original language	English
Pages (from-to)	168-177
Number of pages	10
Journal	Particuology
Volume	84
DOIs	https://doi.org/10.1016/j.partic.2023.06.006
State	Published - Jan 2024
Externally published	Yes

Keywords

Microcapsule
Reductive-responsive
Sodium alginate
Sonochemical
Targeted delivery

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10.1016/j.partic.2023.06.006

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title = "Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release",

abstract = "In this study, sodium alginate (SA), a non-toxic natural polysaccharide with good biocompatibility and biodegradability, was developed for targeted delivery of curcumin (CUR) in tumor therapy. The strategy is to sulfhydrylate the folic acid (FA) modified SA, and the CUR dissolved in ethyl acetate (EAC) phase is coated in microcapsules by a quick, efficient and environment-friendly sonochemical method. The EAC in the microcapsule core is volatile, which can be recycled and reused to reduce cost. The prepared microcapsules (FA-RSMCs@CUR) exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro. FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro. It is expected to become a low-cost tumor targeting vector in the future, and has the potential to be promoted in clinical application.",

keywords = "Microcapsule, Reductive-responsive, Sodium alginate, Sonochemical, Targeted delivery",

author = "Qingye Meng and Shuangling Zhong and Jingfei Wang and Zhenqian Zhang and Yan Gao and Xuejun Cui",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2024",

month = jan,

doi = "10.1016/j.partic.2023.06.006",

language = "英语",

volume = "84",

pages = "168--177",

journal = "Particuology",

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T1 - Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

AU - Meng, Qingye

AU - Zhong, Shuangling

AU - Wang, Jingfei

AU - Zhang, Zhenqian

AU - Gao, Yan

AU - Cui, Xuejun

PY - 2024/1

Y1 - 2024/1

N2 - In this study, sodium alginate (SA), a non-toxic natural polysaccharide with good biocompatibility and biodegradability, was developed for targeted delivery of curcumin (CUR) in tumor therapy. The strategy is to sulfhydrylate the folic acid (FA) modified SA, and the CUR dissolved in ethyl acetate (EAC) phase is coated in microcapsules by a quick, efficient and environment-friendly sonochemical method. The EAC in the microcapsule core is volatile, which can be recycled and reused to reduce cost. The prepared microcapsules (FA-RSMCs@CUR) exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro. FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro. It is expected to become a low-cost tumor targeting vector in the future, and has the potential to be promoted in clinical application.

AB - In this study, sodium alginate (SA), a non-toxic natural polysaccharide with good biocompatibility and biodegradability, was developed for targeted delivery of curcumin (CUR) in tumor therapy. The strategy is to sulfhydrylate the folic acid (FA) modified SA, and the CUR dissolved in ethyl acetate (EAC) phase is coated in microcapsules by a quick, efficient and environment-friendly sonochemical method. The EAC in the microcapsule core is volatile, which can be recycled and reused to reduce cost. The prepared microcapsules (FA-RSMCs@CUR) exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro. FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro. It is expected to become a low-cost tumor targeting vector in the future, and has the potential to be promoted in clinical application.

KW - Microcapsule

KW - Reductive-responsive

KW - Sodium alginate

KW - Sonochemical

KW - Targeted delivery

UR - https://www.scopus.com/pages/publications/85163427162

U2 - 10.1016/j.partic.2023.06.006

DO - 10.1016/j.partic.2023.06.006

M3 - 文章

AN - SCOPUS:85163427162

SN - 1674-2001

VL - 84

SP - 168

EP - 177

JO - Particuology

JF - Particuology

ER -

Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

Abstract

Keywords

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