TY - GEN
T1 - Study on the Effectiveness of Focused Microwave Stimulation in Improving Motor Dysfunction in Stroke Rats
AU - Li, Sinan
AU - Wu, Linyan
AU - Shang, Sen
AU - Wen, Bin
AU - Chen, Jiawen
AU - Yuan, Ye
AU - Li, Long
AU - Liu, Tian
AU - Wang, Jue
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - This paper presents a non-invasive microwave brain stimulation system for improving motor function after a stroke. The system uses a small circular antenna to generate 6.0 GHz focused pulsed signals, effectively stimulating rat brains. Unlike traditional methods using DC or AC, this system employs centimeter-wave microwaves for non-invasive, precise stimulation. It uses a frequency synthesizer chip with a voltage-controlled oscillator (VCO) for stable signal generation. The circular design enhances the main lobe energy, reduces side lobe energy, and focuses microwave energy on the central unit. We tested the system with a 5 dBm power, 1 Hz pulse, and 50% duty cycle on rats for 20 minutes. The local field potentials (LFPs) from the primary and secondary motor cortices (M1, M2 regions) showed an increased power spectrum. Brain temperature was monitored during stimulation. A 14-day behavioral study confirmed the method's safety and effectiveness, showing improved motor function in stroke-affected rats. This study demonstrates that non-thermal microwave radiation can positively affect brain neurons.
AB - This paper presents a non-invasive microwave brain stimulation system for improving motor function after a stroke. The system uses a small circular antenna to generate 6.0 GHz focused pulsed signals, effectively stimulating rat brains. Unlike traditional methods using DC or AC, this system employs centimeter-wave microwaves for non-invasive, precise stimulation. It uses a frequency synthesizer chip with a voltage-controlled oscillator (VCO) for stable signal generation. The circular design enhances the main lobe energy, reduces side lobe energy, and focuses microwave energy on the central unit. We tested the system with a 5 dBm power, 1 Hz pulse, and 50% duty cycle on rats for 20 minutes. The local field potentials (LFPs) from the primary and secondary motor cortices (M1, M2 regions) showed an increased power spectrum. Brain temperature was monitored during stimulation. A 14-day behavioral study confirmed the method's safety and effectiveness, showing improved motor function in stroke-affected rats. This study demonstrates that non-thermal microwave radiation can positively affect brain neurons.
KW - Brain Stimulation System
KW - Microstrip Antenna
KW - Neural Modulation
UR - https://www.scopus.com/pages/publications/85215104876
U2 - 10.1109/i-CREATe62067.2024.10776465
DO - 10.1109/i-CREATe62067.2024.10776465
M3 - 会议稿件
AN - SCOPUS:85215104876
T3 - 2024 17th International Convention on Rehabilitation Engineering and Assistive Technology, i-CREATe 2024 and World Rehabilitation Robot Convention, WRRC 2024 - Proceedings
BT - 2024 17th International Convention on Rehabilitation Engineering and Assistive Technology, i-CREATe 2024 and World Rehabilitation Robot Convention, WRRC 2024 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 17th International Convention on Rehabilitation Engineering and Assistive Technology, i-CREATe 2024
Y2 - 23 August 2024 through 26 August 2024
ER -