Sweet signaling for ferroptosis

Fan Yu; Lingyu Jiang; Quan Chen

doi:10.1016/j.chembiol.2025.08.012

Sweet signaling for ferroptosis

Fan Yu
, Lingyu Jiang
, Quan Chen

School of Life Science and Health

Nankai University

Research output: Contribution to journal › Comment/debate

Abstract

A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.¹ Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.

Original language	English
Pages (from-to)	1097-1098
Number of pages	2
Journal	Cell Chemical Biology
Volume	32
Issue number	9
DOIs	https://doi.org/10.1016/j.chembiol.2025.08.012
State	Published - 18 Sep 2025

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10.1016/j.chembiol.2025.08.012

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@article{34b63cf62a614b4a8d00e31d0b669e99,

title = "Sweet signaling for ferroptosis",

abstract = "A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.",

author = "Fan Yu and Lingyu Jiang and Quan Chen",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = sep,

day = "18",

doi = "10.1016/j.chembiol.2025.08.012",

language = "英语",

volume = "32",

pages = "1097--1098",

journal = "Cell Chemical Biology",

issn = "2451-9456",

publisher = "Elsevier Ltd",

number = "9",

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TY - JOUR

T1 - Sweet signaling for ferroptosis

AU - Yu, Fan

AU - Jiang, Lingyu

AU - Chen, Quan

PY - 2025/9/18

Y1 - 2025/9/18

N2 - A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.

AB - A recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death. This axis fuels HCC progression and therapy resistance, highlighting its therapeutic potential.

UR - https://www.scopus.com/pages/publications/105015639250

U2 - 10.1016/j.chembiol.2025.08.012

DO - 10.1016/j.chembiol.2025.08.012

M3 - 评论/辩论

C2 - 40972519

AN - SCOPUS:105015639250

SN - 2451-9456

VL - 32

SP - 1097

EP - 1098

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 9

ER -

Sweet signaling for ferroptosis

Abstract

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