Tensor decomposition based on the potential low-rank and p -shrinkage generalized threshold algorithm for analyzing cancer multiomics data

  • Hang Jin Yang
  • , Yu Xia Lei
  • , Juan Wang
  • , Xiang Zhen Kong
  • , Jin Xing Liu
  • , Ying Lian Gao

Research output: Contribution to journalArticlepeer-review

Abstract

Tensor Robust Principal Component Analysis (TRPCA) has achieved promising results in the analysis of genomics data. However, the TRPCA model under the existing tensor singular value decomposition (t-SVD) framework insufficiently extracts the potential low-rank structure of the data, resulting in suboptimal restored components. Simultaneously, the tensor nuclear norm (TNN) defined based on t-SVD uses the same standard to handle various singular values. TNN ignores the difference of singular values, leading to the failure of the main information that needs to be well preserved. To preserve the heterogeneous structure in the low-rank information, we propose a novel TNN and extend it to the TRPCA model. Potential low-rank space may contain important information. We learn the low-rank structural information from the core tensor. The singular value space contains the association information between genes and cancers. The p-shrinkage generalized threshold function is utilized to preserve the low-rank properties of larger singular values. The optimization problem is solved by the alternating direction method of the multiplier (ADMM) algorithm. Clustering and feature selection experiments are performed on the TCGA data set. The experimental results show that the proposed model is more promising than other state-of-the-art tensor decomposition methods.

Original languageEnglish
Article number2250002
JournalJournal of Bioinformatics and Computational Biology
Volume20
Issue number2
DOIs
StatePublished - 1 Apr 2022
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Low-rank space
  • p -shrinkage threshold function
  • sample clustering
  • tensor singular value

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