The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain

Hao Kang; Shanshan Cao; Tingjun Chen; Zhaocai Jiang; Zihao Liu; Zhaohui Li; Yangang Wei; Nanping Ai; Quangang Xu; Qing Lin; Shihui Wei

doi:10.1016/j.jneuroim.2015.10.005

The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain

Hao Kang
, Shanshan Cao
, Tingjun Chen
, Zhaocai Jiang
, Zihao Liu
, Zhaohui Li
, Yangang Wei
, Nanping Ai
, Quangang Xu
, Qing Lin
, Shihui Wei

The Chinese People's Liberation Army General Hospital
Beijing Longfu Hospital
Dongzhimen Hospital of Beijing University of Chinese Medicine
Bioori Translational Medicine Center
University of Texas at Arlington

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Neuromyelitis optica spectrum disorders (NMOSDs) are blindness-causing neuritis. In NMOSD patients, NMO-IgG evokes astrocytopathy that in turn causes demyelination. While measurement of NMO-IgG titer will help neurologists make the diagnosis of NMOSDs, it is not sufficient to evaluate the severity of astrocytopathy. In this study, we compared the different levels of an astrocyte biomarker in cerebrospinal fluid of NMOSD patients with good or poor recovery, and then linked their differences to the changes in remyelinating promoter (CXCL12) levels. Our results indicate that NMO-IgG down-regulated CXCL12 and impaired the remyelinating process, this may be a mechanism contributing to the poor recovery of NMOSDs.

Original language	English
Pages (from-to)	56-61
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	289
DOIs	https://doi.org/10.1016/j.jneuroim.2015.10.005
State	Published - 15 Dec 2015
Externally published	Yes

Keywords

Aquaporin 4 (AQP4)
CXC-motif ligand 12 (CXCL12)
Glial fibrillary acidic protein (GFAP)
Neuromyelitis optica spectrum disorders (NMOSDs)
Tumor necrosis factor α (TNFα)

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10.1016/j.jneuroim.2015.10.005

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@article{c3002497efb043c08d70bcf863e54c71,

title = "The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain",

abstract = "Neuromyelitis optica spectrum disorders (NMOSDs) are blindness-causing neuritis. In NMOSD patients, NMO-IgG evokes astrocytopathy that in turn causes demyelination. While measurement of NMO-IgG titer will help neurologists make the diagnosis of NMOSDs, it is not sufficient to evaluate the severity of astrocytopathy. In this study, we compared the different levels of an astrocyte biomarker in cerebrospinal fluid of NMOSD patients with good or poor recovery, and then linked their differences to the changes in remyelinating promoter (CXCL12) levels. Our results indicate that NMO-IgG down-regulated CXCL12 and impaired the remyelinating process, this may be a mechanism contributing to the poor recovery of NMOSDs.",

keywords = "Aquaporin 4 (AQP4), CXC-motif ligand 12 (CXCL12), Glial fibrillary acidic protein (GFAP), Neuromyelitis optica spectrum disorders (NMOSDs), Tumor necrosis factor α (TNFα)",

author = "Hao Kang and Shanshan Cao and Tingjun Chen and Zhaocai Jiang and Zihao Liu and Zhaohui Li and Yangang Wei and Nanping Ai and Quangang Xu and Qing Lin and Shihui Wei",

note = "Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2015.10.005",

language = "英语",

volume = "289",

pages = "56--61",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain

AU - Kang, Hao

AU - Cao, Shanshan

AU - Chen, Tingjun

AU - Jiang, Zhaocai

AU - Liu, Zihao

AU - Li, Zhaohui

AU - Wei, Yangang

AU - Ai, Nanping

AU - Xu, Quangang

AU - Lin, Qing

AU - Wei, Shihui

PY - 2015/12/15

Y1 - 2015/12/15

N2 - Neuromyelitis optica spectrum disorders (NMOSDs) are blindness-causing neuritis. In NMOSD patients, NMO-IgG evokes astrocytopathy that in turn causes demyelination. While measurement of NMO-IgG titer will help neurologists make the diagnosis of NMOSDs, it is not sufficient to evaluate the severity of astrocytopathy. In this study, we compared the different levels of an astrocyte biomarker in cerebrospinal fluid of NMOSD patients with good or poor recovery, and then linked their differences to the changes in remyelinating promoter (CXCL12) levels. Our results indicate that NMO-IgG down-regulated CXCL12 and impaired the remyelinating process, this may be a mechanism contributing to the poor recovery of NMOSDs.

AB - Neuromyelitis optica spectrum disorders (NMOSDs) are blindness-causing neuritis. In NMOSD patients, NMO-IgG evokes astrocytopathy that in turn causes demyelination. While measurement of NMO-IgG titer will help neurologists make the diagnosis of NMOSDs, it is not sufficient to evaluate the severity of astrocytopathy. In this study, we compared the different levels of an astrocyte biomarker in cerebrospinal fluid of NMOSD patients with good or poor recovery, and then linked their differences to the changes in remyelinating promoter (CXCL12) levels. Our results indicate that NMO-IgG down-regulated CXCL12 and impaired the remyelinating process, this may be a mechanism contributing to the poor recovery of NMOSDs.

KW - Aquaporin 4 (AQP4)

KW - CXC-motif ligand 12 (CXCL12)

KW - Glial fibrillary acidic protein (GFAP)

KW - Neuromyelitis optica spectrum disorders (NMOSDs)

KW - Tumor necrosis factor α (TNFα)

UR - https://www.scopus.com/pages/publications/84947921775

U2 - 10.1016/j.jneuroim.2015.10.005

DO - 10.1016/j.jneuroim.2015.10.005

M3 - 文章

C2 - 26616871

AN - SCOPUS:84947921775

SN - 0165-5728

VL - 289

SP - 56

EP - 61

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain

Abstract

Keywords

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