Abstract
Both iron and alpha-synuclein accumulation are one of hallmarks of Parkinson's disease (PD). Alpha-synuclein aggregation is often accompanied by abnormal accumulation of iron, indicating that there is a certain link between iron and alpha-synuclein aggregation. Iron promotes alpha-synuclein aggregation by increasing its synthesis and decreasing its degradation. Also, alpha-synuclein regulates iron metabolism through its ferrireductase activity. In this review, we will describe the roles of iron and alpha-synuclein in PD pathogenesis, and the mechanisms of iron and alpha-synuclein interaction.
| Original language | English |
|---|---|
| Pages (from-to) | 180-184 |
| Number of pages | 5 |
| Journal | Sheng li ke xue jin zhan [Progress in physiology] |
| Volume | 46 |
| Issue number | 3 |
| State | Published - 1 Jun 2015 |
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