The visualization of hERG channels in living cells: Via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline

Zhen Qiao; Qiqi Zhou; Hongyi Zhang; Ningning Wei; Yanru Zhang; Kewei Wang

doi:10.1039/c9cc01735f

The visualization of hERG channels in living cells: Via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline

Zhen Qiao
, Qiqi Zhou
, Hongyi Zhang
, Ningning Wei
, Yanru Zhang
, Kewei Wang

Qingdao University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A highly sensitive fluorescent probe CBH based on solvatochromism and molecular rotation was designed and developed for imaging of hERG channels by employing a novel targeting group 4-benzylaniline. More importantly, CBH has the potential for the quantitative analysis of the hERG channels expressed in tumor cells.

Original language	English
Pages (from-to)	5515-5518
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	38
DOIs	https://doi.org/10.1039/c9cc01735f
State	Published - 2019
Externally published	Yes

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10.1039/c9cc01735f

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title = "The visualization of hERG channels in living cells: Via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline",

abstract = "A highly sensitive fluorescent probe CBH based on solvatochromism and molecular rotation was designed and developed for imaging of hERG channels by employing a novel targeting group 4-benzylaniline. More importantly, CBH has the potential for the quantitative analysis of the hERG channels expressed in tumor cells.",

author = "Zhen Qiao and Qiqi Zhou and Hongyi Zhang and Ningning Wei and Yanru Zhang and Kewei Wang",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9cc01735f",

language = "英语",

volume = "55",

pages = "5515--5518",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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}

The visualization of hERG channels in living cells: Via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline. / Qiao, Zhen; Zhou, Qiqi; Zhang, Hongyi et al.
In: Chemical Communications, Vol. 55, No. 38, 2019, p. 5515-5518.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The visualization of hERG channels in living cells

T2 - Via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline

AU - Qiao, Zhen

AU - Zhou, Qiqi

AU - Zhang, Hongyi

AU - Wei, Ningning

AU - Zhang, Yanru

AU - Wang, Kewei

PY - 2019

Y1 - 2019

N2 - A highly sensitive fluorescent probe CBH based on solvatochromism and molecular rotation was designed and developed for imaging of hERG channels by employing a novel targeting group 4-benzylaniline. More importantly, CBH has the potential for the quantitative analysis of the hERG channels expressed in tumor cells.

AB - A highly sensitive fluorescent probe CBH based on solvatochromism and molecular rotation was designed and developed for imaging of hERG channels by employing a novel targeting group 4-benzylaniline. More importantly, CBH has the potential for the quantitative analysis of the hERG channels expressed in tumor cells.

UR - https://www.scopus.com/pages/publications/85065490933

U2 - 10.1039/c9cc01735f

DO - 10.1039/c9cc01735f

M3 - 文章

C2 - 31020283

AN - SCOPUS:85065490933

SN - 1359-7345

VL - 55

SP - 5515

EP - 5518

JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

The visualization of hERG channels in living cells: Via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline

Abstract

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