Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111).

Dong Huang; Junshi Li; Zhongyan Wang; Zhitong Zhang; Qining Wang; Zhihong Li

doi:10.1109/NEMS51815.2021.9451272

Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111).

Dong Huang
, Junshi Li
, Zhongyan Wang
, Zhitong Zhang
, Qining Wang
, Zhihong Li

Peking University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this paper, we proposed a flexible neuro probe with the biodegradable microneedle as a carrier for reliable and long-term neuro recording. The ultra-thin Parylene microelectrode mesh was assembled on a needle-shaped collagen suture with assistance of surface tension. After penetration into brain, the collagen suture can be degraded and absorbed gradually, resulting in the recovery of the glial scar and leaving ultra-thin Parylene mesh embedded in tissue. Hence, such a strategy can significantly reduce the potential safety hazard and conduct satisfactory contact between microelectrodes and nerve cells in the long-term implantation. This device is expected to offer a general tool for experimental neuroscience study and clinic application.

Original language	English
Title of host publication	Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1839-1842
Number of pages	4
ISBN (Electronic)	9781665419413
DOIs	https://doi.org/10.1109/NEMS51815.2021.9451272
State	Published - 25 Apr 2021
Externally published	Yes
Event	16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021 - Xiamen, China Duration: 25 Apr 2021 → 29 Apr 2021

Publication series

Name	Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021

Conference

Conference	16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021
Country/Territory	China
City	Xiamen
Period	25/04/21 → 29/04/21

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10.1109/NEMS51815.2021.9451272

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Huang, D., Li, J., Wang, Z., Zhang, Z., Wang, Q., & Li, Z. (2021). Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111). In Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021 (pp. 1839-1842). Article 9451272 (Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS51815.2021.9451272

Huang, Dong ; Li, Junshi ; Wang, Zhongyan et al. / Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111). Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 1839-1842 (Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021).

@inproceedings{ff1e6720ea5c477a9d3081a52aca13a7,

title = "Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111).",

abstract = "In this paper, we proposed a flexible neuro probe with the biodegradable microneedle as a carrier for reliable and long-term neuro recording. The ultra-thin Parylene microelectrode mesh was assembled on a needle-shaped collagen suture with assistance of surface tension. After penetration into brain, the collagen suture can be degraded and absorbed gradually, resulting in the recovery of the glial scar and leaving ultra-thin Parylene mesh embedded in tissue. Hence, such a strategy can significantly reduce the potential safety hazard and conduct satisfactory contact between microelectrodes and nerve cells in the long-term implantation. This device is expected to offer a general tool for experimental neuroscience study and clinic application.",

author = "Dong Huang and Junshi Li and Zhongyan Wang and Zhitong Zhang and Qining Wang and Zhihong Li",

note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021 ; Conference date: 25-04-2021 Through 29-04-2021",

year = "2021",

month = apr,

day = "25",

doi = "10.1109/NEMS51815.2021.9451272",

language = "英语",

series = "Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1839--1842",

booktitle = "Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021",

}

Huang, D, Li, J, Wang, Z, Zhang, Z, Wang, Q & Li, Z 2021, Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111). in Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021., 9451272, Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021, Institute of Electrical and Electronics Engineers Inc., pp. 1839-1842, 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021, Xiamen, China, 25/04/21. https://doi.org/10.1109/NEMS51815.2021.9451272

Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111). / Huang, Dong; Li, Junshi; Wang, Zhongyan et al.
Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 1839-1842 9451272 (Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Huang, Dong

AU - Li, Junshi

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AU - Zhang, Zhitong

AU - Wang, Qining

AU - Li, Zhihong

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AB - In this paper, we proposed a flexible neuro probe with the biodegradable microneedle as a carrier for reliable and long-term neuro recording. The ultra-thin Parylene microelectrode mesh was assembled on a needle-shaped collagen suture with assistance of surface tension. After penetration into brain, the collagen suture can be degraded and absorbed gradually, resulting in the recovery of the glial scar and leaving ultra-thin Parylene mesh embedded in tissue. Hence, such a strategy can significantly reduce the potential safety hazard and conduct satisfactory contact between microelectrodes and nerve cells in the long-term implantation. This device is expected to offer a general tool for experimental neuroscience study and clinic application.

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BT - Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021

PB - Institute of Electrical and Electronics Engineers Inc.

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ER -

Huang D, Li J, Wang Z, Zhang Z, Wang Q, Li Z. Ultra-thin Flexible Neuro Probe Utilizing Biodegradable Collagen Microneedle∗∗Resrach supported by National Natural Science Foundation of China (62004007), National Key Research and Development Program (2016YFA0200802), China Postdoctoral Science Foundation Grant (2019M660309), and the China Capital Health Research and Development of Special (2018-1-4111). In Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 1839-1842. 9451272. (Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021). doi: 10.1109/NEMS51815.2021.9451272

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