Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats

Qiang Su; Weiwei Tao; Hanqing Wang; Yanyan Chen; Huang Huang; Gang Chen

doi:10.1002/iub.1496

Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats

Qiang Su
, Weiwei Tao
, Hanqing Wang
, Yanyan Chen
, Huang Huang
, Gang Chen

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The aim of this study was to investigate whether umbelliferone (Umb) could attenuate insulin resistance in unpredictable chronic mild stress (CUMS)-induced rats. Behavioral changes were evaluated through sucrose preference test (SPT), open-field test, forced swimming test, and tail suspension test (TST), suggesting that Umb (20 and 40 mg/kg) could effectively improve depression symptoms. Oral glucose tolerance test and serum insulin indicated that Umb attributed to the control of blood glucose levels. The phosphorylation of insulin receptor, insulin receptor substrate (IRS)-1, glycogen synthase kinase-3β, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis. Taken together, the current results suggested the ameliorative effect of Umb against insulin resistance in the CUMS-induced rats.

Original language	English
Pages (from-to)	403-409
Number of pages	7
Journal	IUBMB Life
Volume	68
Issue number	5
DOIs	https://doi.org/10.1002/iub.1496
State	Published - 1 May 2016
Externally published	Yes

Keywords

PI3K/Akt
insulin resistance
umbelliferone
unpredictable chronic mild stress

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10.1002/iub.1496

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title = "Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats",

abstract = "The aim of this study was to investigate whether umbelliferone (Umb) could attenuate insulin resistance in unpredictable chronic mild stress (CUMS)-induced rats. Behavioral changes were evaluated through sucrose preference test (SPT), open-field test, forced swimming test, and tail suspension test (TST), suggesting that Umb (20 and 40 mg/kg) could effectively improve depression symptoms. Oral glucose tolerance test and serum insulin indicated that Umb attributed to the control of blood glucose levels. The phosphorylation of insulin receptor, insulin receptor substrate (IRS)-1, glycogen synthase kinase-3β, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis. Taken together, the current results suggested the ameliorative effect of Umb against insulin resistance in the CUMS-induced rats.",

keywords = "PI3K/Akt, insulin resistance, umbelliferone, unpredictable chronic mild stress",

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AU - Su, Qiang

AU - Tao, Weiwei

AU - Wang, Hanqing

AU - Chen, Yanyan

AU - Huang, Huang

AU - Chen, Gang

PY - 2016/5/1

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AB - The aim of this study was to investigate whether umbelliferone (Umb) could attenuate insulin resistance in unpredictable chronic mild stress (CUMS)-induced rats. Behavioral changes were evaluated through sucrose preference test (SPT), open-field test, forced swimming test, and tail suspension test (TST), suggesting that Umb (20 and 40 mg/kg) could effectively improve depression symptoms. Oral glucose tolerance test and serum insulin indicated that Umb attributed to the control of blood glucose levels. The phosphorylation of insulin receptor, insulin receptor substrate (IRS)-1, glycogen synthase kinase-3β, PI3K, and Akt was increased in Umb (20 and 40 mg/kg) treatment according to Western blot analysis. Taken together, the current results suggested the ameliorative effect of Umb against insulin resistance in the CUMS-induced rats.

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KW - umbelliferone

KW - unpredictable chronic mild stress

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Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats

Abstract

Keywords

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