A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

Seung Wook Yang; Lei Li; Jon P. Connelly; Shaina N. Porter; Kiran Kodali; Haiyun Gan; Jung Mi Park; Klementina Fon Tacer; Heather Tillman; Junmin Peng; Shondra M. Pruett-Miller; Wei Li; Patrick Ryan Potts

doi:10.1016/j.molcel.2019.12.022

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

Seung Wook Yang
, Lei Li
, Jon P. Connelly
, Shaina N. Porter
, Kiran Kodali
, Haiyun Gan
, Jung Mi Park
, Klementina Fon Tacer
, Heather Tillman
, Junmin Peng
, Shondra M. Pruett-Miller
, Wei Li
, Patrick Ryan Potts

科研成果: 期刊稿件 › 文章 › 同行评审

58 引用（Scopus）

摘要

Yang et al. show that the germ-cell-restricted MAGE-A11 is aberrantly expressed in tumors and drives tumorigenesis through ubiquitination of PCF11, a component of the 3′-mRNA processing complex. PCF11 ubiquitination results in alternative polyadenylation of transcripts leading to 3′ UTR shortening.

源语言	英语
页（从-至）	1206-1221.e7
期刊	Molecular Cell
卷	77
期	6
DOI	https://doi.org/10.1016/j.molcel.2019.12.022
出版状态	已出版 - 19 3月 2020
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1016/j.molcel.2019.12.022

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Yang, S. W., Li, L., Connelly, J. P., Porter, S. N., Kodali, K., Gan, H., Park, J. M., Tacer, K. F., Tillman, H., Peng, J., Pruett-Miller, S. M., Li, W., & Potts, P. R. (2020). A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex. Molecular Cell, 77(6), 1206-1221.e7. https://doi.org/10.1016/j.molcel.2019.12.022

@article{546383de768b4633baded3d11a4e8f0d,

title = "A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex",

abstract = "Yang et al. show that the germ-cell-restricted MAGE-A11 is aberrantly expressed in tumors and drives tumorigenesis through ubiquitination of PCF11, a component of the 3′-mRNA processing complex. PCF11 ubiquitination results in alternative polyadenylation of transcripts leading to 3′ UTR shortening.",

keywords = "3′ UTR shortening, 3′ end processing complex, CFIm25, HUWE1, MAGE-A11, PCF11, PTEN, alternative polyadenylation, cyclin D2, ubiquitin",

author = "Yang, \{Seung Wook\} and Lei Li and Connelly, \{Jon P.\} and Porter, \{Shaina N.\} and Kiran Kodali and Haiyun Gan and Park, \{Jung Mi\} and Tacer, \{Klementina Fon\} and Heather Tillman and Junmin Peng and Pruett-Miller, \{Shondra M.\} and Wei Li and Potts, \{Patrick Ryan\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = mar,

day = "19",

doi = "10.1016/j.molcel.2019.12.022",

language = "英语",

volume = "77",

pages = "1206--1221.e7",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "6",

}

Yang, SW, Li, L, Connelly, JP, Porter, SN, Kodali, K, Gan, H, Park, JM, Tacer, KF, Tillman, H, Peng, J, Pruett-Miller, SM, Li, W & Potts, PR 2020, 'A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex', Molecular Cell, 卷 77, 号码 6, 页码 1206-1221.e7. https://doi.org/10.1016/j.molcel.2019.12.022

TY - JOUR

T1 - A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

AU - Yang, Seung Wook

AU - Li, Lei

AU - Connelly, Jon P.

AU - Porter, Shaina N.

AU - Kodali, Kiran

AU - Gan, Haiyun

AU - Park, Jung Mi

AU - Tacer, Klementina Fon

AU - Tillman, Heather

AU - Peng, Junmin

AU - Pruett-Miller, Shondra M.

AU - Li, Wei

AU - Potts, Patrick Ryan

PY - 2020/3/19

Y1 - 2020/3/19

N2 - Yang et al. show that the germ-cell-restricted MAGE-A11 is aberrantly expressed in tumors and drives tumorigenesis through ubiquitination of PCF11, a component of the 3′-mRNA processing complex. PCF11 ubiquitination results in alternative polyadenylation of transcripts leading to 3′ UTR shortening.

AB - Yang et al. show that the germ-cell-restricted MAGE-A11 is aberrantly expressed in tumors and drives tumorigenesis through ubiquitination of PCF11, a component of the 3′-mRNA processing complex. PCF11 ubiquitination results in alternative polyadenylation of transcripts leading to 3′ UTR shortening.

KW - 3′ UTR shortening

KW - 3′ end processing complex

KW - CFIm25

KW - HUWE1

KW - MAGE-A11

KW - PCF11

KW - PTEN

KW - alternative polyadenylation

KW - cyclin D2

KW - ubiquitin

UR - https://www.scopus.com/pages/publications/85081690764

U2 - 10.1016/j.molcel.2019.12.022

DO - 10.1016/j.molcel.2019.12.022

M3 - 文章

C2 - 31980388

AN - SCOPUS:85081690764

SN - 1097-2765

VL - 77

SP - 1206-1221.e7

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

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