A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang; Wentao Li; Dubravka Drabek; Nisreen M.A. Okba; Rien van Haperen; Albert D.M.E. Osterhaus; Frank J.M. van Kuppeveld; Bart L. Haagmans; Frank Grosveld; Berend Jan Bosch

doi:10.1038/s41467-020-16256-y

A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang
, Wentao Li
, Dubravka Drabek
, Nisreen M.A. Okba
, Rien van Haperen
, Albert D.M.E. Osterhaus
, Frank J.M. van Kuppeveld
, Bart L. Haagmans
, Frank Grosveld
, Berend Jan Bosch

Utrecht University
Erasmus University Rotterdam
Harbour BioMed
University of Veterinary Medicine Hannover, Foundation

科研成果: 期刊稿件 › 文章 › 同行评审

866 引用（Scopus）

摘要

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

源语言	英语
文章编号	2251
期刊	Nature Communications
卷	11
期	1
DOI	https://doi.org/10.1038/s41467-020-16256-y
出版状态	已出版 - 1 12月 2020
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1038/s41467-020-16256-y

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author = "Chunyan Wang and Wentao Li and Dubravka Drabek and Okba, \{Nisreen M.A.\} and \{van Haperen\}, Rien and Osterhaus, \{Albert D.M.E.\} and \{van Kuppeveld\}, \{Frank J.M.\} and Haagmans, \{Bart L.\} and Frank Grosveld and Bosch, \{Berend Jan\}",

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AU - Wang, Chunyan

AU - Li, Wentao

AU - Drabek, Dubravka

AU - Okba, Nisreen M.A.

AU - van Haperen, Rien

AU - Osterhaus, Albert D.M.E.

AU - van Kuppeveld, Frank J.M.

AU - Haagmans, Bart L.

AU - Grosveld, Frank

AU - Bosch, Berend Jan

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

AB - The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

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DO - 10.1038/s41467-020-16256-y

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SN - 2041-1723

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JO - Nature Communications

JF - Nature Communications

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ER -

A human monoclonal antibody blocking SARS-CoV-2 infection

摘要

联合国可持续发展目标

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