TY - JOUR
T1 - A locus for nonspecific X-linked mental retardation mapped to a 22.3 cM region of Xp11.3-q22.3
AU - Zhang, Xiyu
AU - Liu, Qiji
AU - Chen, Bingxi
AU - Guo, Chenhong
AU - Li, Jiangxia
AU - Gao, Guimin
AU - Guo, Yishou
AU - Gong, Yaoqin
PY - 2004/9/1
Y1 - 2004/9/1
N2 - By using several microsatellite markers scattered along the X chromosome, we studied a Chinese family with nonspecific X-linked mental retardation (MRX84) to search for a region including the MRX84 locus that was linked to the markers. Two-point linkage analysis demonstrated linkage between the disorder and several markers located at Xq22.2, with maximum LOD score Zmax = 2.41 at recombination fraction 0 = 0 for DXS1191 and DXS1230, respectively. Recombination events were observed with flanking markers DXS8080 and DXS456, located at Xp11.3 and Xq22.3, respectively, and a region of approximately 22.3 cM was defined. Accordingly, markers distal to Xp11.3 and Xq22.3 segregated independently of the disease. The localized region observed in this Chinese family overlaps with 29 other MRX loci previously reported in Xp11.3-q22.3. These results should contribute to the identification of the disease gene for the MRX84 disorder.
AB - By using several microsatellite markers scattered along the X chromosome, we studied a Chinese family with nonspecific X-linked mental retardation (MRX84) to search for a region including the MRX84 locus that was linked to the markers. Two-point linkage analysis demonstrated linkage between the disorder and several markers located at Xq22.2, with maximum LOD score Zmax = 2.41 at recombination fraction 0 = 0 for DXS1191 and DXS1230, respectively. Recombination events were observed with flanking markers DXS8080 and DXS456, located at Xp11.3 and Xq22.3, respectively, and a region of approximately 22.3 cM was defined. Accordingly, markers distal to Xp11.3 and Xq22.3 segregated independently of the disease. The localized region observed in this Chinese family overlaps with 29 other MRX loci previously reported in Xp11.3-q22.3. These results should contribute to the identification of the disease gene for the MRX84 disorder.
KW - Gene mapping
KW - Linkage analysis
KW - Microsatellite markers
KW - X-linked nonspecific mental retardation (MRX)
UR - https://www.scopus.com/pages/publications/4444318119
U2 - 10.1002/ajmg.a.30121
DO - 10.1002/ajmg.a.30121
M3 - 文章
C2 - 15326629
AN - SCOPUS:4444318119
SN - 1552-4825
VL - 129 A
SP - 286
EP - 289
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
IS - 3
ER -