摘要
Along with the rapid development of high-throughput sequencing technology, a large amount of multi-omics data sets are generated, which provide more opportunities to understand the mechanism of complex diseases. In this study, an improved particle swarm optimization with dynamic scale-free network, named DSFPSO, is proposed for detecting multi-omics features. The highlights of DSFPSO are the introduced scale-free network and velocity updating strategies. The scale-free network is employed to DSFPSO as its population structure, which can dynamically adjust the iteration processes. Three types of velocity updating strategies are used in DSFPSO for fully considering the heterogeneity of particles and their neighbors. Both gene function analysis and pathway analysis on colorectal cancer (CRC) data show that DSFPSO can detect CRC-associated features effectively.
| 源语言 | 英语 |
|---|---|
| 主期刊名 | Bioinformatics Research and Applications - 14th International Symposium, ISBRA 2018, Proceedings |
| 编辑 | Fa Zhang, Shihua Zhang, Zhipeng Cai, Pavel Skums |
| 出版商 | Springer Verlag |
| 页 | 26-37 |
| 页数 | 12 |
| ISBN(印刷版) | 9783319949673 |
| DOI | |
| 出版状态 | 已出版 - 2018 |
| 已对外发布 | 是 |
| 活动 | 14th International Symposium on Bioinformatics Research and Applications, ISBRA 2018 - Beijing, 中国 期限: 8 6月 2018 → 11 6月 2018 |
出版系列
| 姓名 | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
|---|---|
| 卷 | 10847 LNBI |
| ISSN(印刷版) | 0302-9743 |
| ISSN(电子版) | 1611-3349 |
会议
| 会议 | 14th International Symposium on Bioinformatics Research and Applications, ISBRA 2018 |
|---|---|
| 国家/地区 | 中国 |
| 市 | Beijing |
| 时期 | 8/06/18 → 11/06/18 |
联合国可持续发展目标
此成果有助于实现下列可持续发展目标:
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可持续发展目标 3 良好健康与福祉
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