@article{7937291937aa409da1afa4bc2bcc8394,
title = "ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia",
abstract = "Using the oxygen-induced retinopathy (OIR) mouse model for retinopathy of prematurity (ROP), Ran et al. show that oxygen changes trigger ASK1 activation to phosphorylate HDAC6, blocking HDAC6 ubiquitination by VHL and proteasomal degradation. HDAC6 then drives photoreceptor connecting cilium disassembly, which they demonstrate is an early event in OIR pathogenesis.",
keywords = "apoptosis signal-regulating kinase 1, connecting cilium, histone deacetylase 6, oxygen-induced retinopathy, phosphorylation, photoreceptor, proteasome, retina, retinopathy of prematurity, ubiquitination",
author = "Jie Ran and Min Liu and Jie Feng and Haixia Li and Huixian Ma and Ting Song and Yu Cao and Peng Zhou and Yuhan Wu and Yunfan Yang and Yang Yang and Fan Yu and Heng Guo and Liang Zhang and Songbo Xie and Dengwen Li and Jinmin Gao and Xiaomin Zhang and Xueliang Zhu and Jun Zhou",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = may,
day = "4",
doi = "10.1016/j.devcel.2020.03.010",
language = "英语",
volume = "53",
pages = "287--299.e5",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "3",
}