Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Kun Yang; Yu Peng Feng; Yun Qing Li

doi:10.1016/S0006-8993(01)02293-4

Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Kun Yang
, Yu Peng Feng
, Yun Qing Li

Fourth Military Medical University

科研成果: 期刊稿件 › 文章 › 同行评审

10 引用（Scopus）

摘要

We investigated the action of baclofen, an agonist for GABA_B receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABA_A receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABA_B receptor in spinal dorsal horn.

源语言	英语
页（从-至）	320-323
页数	4
期刊	Brain Research
卷	900
期	2
DOI	https://doi.org/10.1016/S0006-8993(01)02293-4
出版状态	已出版 - 11 5月 2001
已对外发布	是

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title = "Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice",

abstract = "We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0\% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4\% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn.",

keywords = "Baclofen, Inhibitory postsynaptic current, Rat, Spinal cord, Substantia gelatinosa, Whole-cell voltage-clamp recording",

author = "Kun Yang and Feng, \{Yu Peng\} and Li, \{Yun Qing\}",

year = "2001",

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doi = "10.1016/S0006-8993(01)02293-4",

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TY - JOUR

T1 - Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

AU - Yang, Kun

AU - Feng, Yu Peng

AU - Li, Yun Qing

PY - 2001/5/11

Y1 - 2001/5/11

N2 - We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn.

AB - We investigated the action of baclofen, an agonist for GABAB receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Aδ fibers. Baclofen (10 μM) reduced the amplitude of Aδ fiber-evoked glycine receptor-mediated IPSCs to 20.9±3.0% (n=13), and GABAA receptor-mediated IPSCs to 18.6±3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABAB receptor in spinal dorsal horn.

KW - Baclofen

KW - Inhibitory postsynaptic current

KW - Rat

KW - Spinal cord

KW - Substantia gelatinosa

KW - Whole-cell voltage-clamp recording

UR - https://www.scopus.com/pages/publications/0035844075

U2 - 10.1016/S0006-8993(01)02293-4

DO - 10.1016/S0006-8993(01)02293-4

M3 - 文章

C2 - 11334813

AN - SCOPUS:0035844075

SN - 0006-8993

VL - 900

SP - 320

EP - 323

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

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