C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

Ze Gang Ma; Jun Wang; Hong Jiang; Jun Xia Xie; Lei Chen

doi:10.1016/j.neulet.2005.02.065

C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

Ze Gang Ma
, Jun Wang
, Hong Jiang
, Jun Xia Xie
, Lei Chen

Medical College of Qingdao University

科研成果: 期刊稿件 › 文章 › 同行评审

6 引用（Scopus）

摘要

C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.

源语言	英语
页（从-至）	102-105
页数	4
期刊	Neuroscience Letters
卷	382
期	1-2
DOI	https://doi.org/10.1016/j.neulet.2005.02.065
出版状态	已出版 - 1 7月 2005
已对外发布	是

访问文件

10.1016/j.neulet.2005.02.065

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{da4cbd5503d84bcdb10930f0bb4120c3,

title = "C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells",

abstract = "C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.",

keywords = "Alzheimer's disease, C31, Voltage-gated calcium channel",

author = "Ma, \{Ze Gang\} and Jun Wang and Hong Jiang and Xie, \{Jun Xia\} and Lei Chen",

year = "2005",

month = jul,

day = "1",

doi = "10.1016/j.neulet.2005.02.065",

language = "英语",

volume = "382",

pages = "102--105",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

AU - Ma, Ze Gang

AU - Wang, Jun

AU - Jiang, Hong

AU - Xie, Jun Xia

AU - Chen, Lei

PY - 2005/7/1

Y1 - 2005/7/1

N2 - C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.

AB - C31, consisting of 31 amino acid residues, is generated from the carboxyl terminal fragments (CTFs) of amyloid precursor protein (APP). It has been shown that C31 causes apoptosis in neurons and is present in brains of Alzheimer disease (AD) patients. Using whole-cell patch clamp techniques, we investigated effects of C31 on voltage-gated calcium channel (VGCC) currents and the protective effects of β-estradiol on PC12 cells. The results demonstrated that C31 induced a significant increase of the VGCC currents in PC12 cells, which was blocked by β-estradiol. These results suggest that modulation of intracellular calcium levels by VGCC may in part be involved in C31 induced neuronal death associated with AD.

KW - Alzheimer's disease

KW - C31

KW - Voltage-gated calcium channel

UR - https://www.scopus.com/pages/publications/19444371487

U2 - 10.1016/j.neulet.2005.02.065

DO - 10.1016/j.neulet.2005.02.065

M3 - 文章

C2 - 15911130

AN - SCOPUS:19444371487

SN - 0304-3940

VL - 382

SP - 102

EP - 105

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

摘要

访问文件

其它文件与链接

指纹图谱

引用此