Correlation and clinical significance between expression of PIK3CA and drug resistance in colorectal carcinoma tissues

Yang Yang Li; Shu Hua Wu; Lu Ying Liu; Yu Hong Zhu

Correlation and clinical significance between expression of PIK3CA and drug resistance in colorectal carcinoma tissues

Yang Yang Li
, Shu Hua Wu
, Lu Ying Liu
, Yu Hong Zhu

Binzhou Medical College

科研成果: 期刊稿件 › 文章 › 同行评审

摘要

OBJECTIVE: To explor the correlation and clinical significance between the expression of PIK3CA and multidrug resistance gene products LRP, GST-π and Topo II in colorectal carcinoma tissues. METHODS: The expressions of PIK3CA, LRP, GST-π and Topo II in 108 patients with colorectal carcinoma were detected by Max Vision™ immunohistochemical technique. The relationship of PIK3CA and drug resistance in colorectal cancer was analyzed. RESULTS: 1) The PIK3CA expression was correlated with the degree of tumor differentiation, TNM stage and lymph node metastasis (P<0.05); 2) The PIK3CA expression was correlated with GST-π and Topo II. CONCLUSION: The PIK3CA expression is correlated with MDR, therefore, detecting the expressions of PIK3CA has the important significance with regard to choosing the individual chemotherapy and prediction of prognosis.

源语言	英语
页（从-至）	933-936
页数	4
期刊	Chinese Journal of Cancer Prevention and Treatment
卷	17
期	12
出版状态	已出版 - 28 6月 2010
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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引用此

@article{08b9627d3e89493dbee93e914b60679b,

title = "Correlation and clinical significance between expression of PIK3CA and drug resistance in colorectal carcinoma tissues",

abstract = "OBJECTIVE: To explor the correlation and clinical significance between the expression of PIK3CA and multidrug resistance gene products LRP, GST-π and Topo II in colorectal carcinoma tissues. METHODS: The expressions of PIK3CA, LRP, GST-π and Topo II in 108 patients with colorectal carcinoma were detected by Max Vision{\texttrademark} immunohistochemical technique. The relationship of PIK3CA and drug resistance in colorectal cancer was analyzed. RESULTS: 1) The PIK3CA expression was correlated with the degree of tumor differentiation, TNM stage and lymph node metastasis (P<0.05); 2) The PIK3CA expression was correlated with GST-π and Topo II. CONCLUSION: The PIK3CA expression is correlated with MDR, therefore, detecting the expressions of PIK3CA has the important significance with regard to choosing the individual chemotherapy and prediction of prognosis.",

keywords = "Colorectal carcinoma, GST-π, LRP, PIK3CA, Topo II",

author = "Li, \{Yang Yang\} and Wu, \{Shu Hua\} and Liu, \{Lu Ying\} and Zhu, \{Yu Hong\}",

year = "2010",

month = jun,

day = "28",

language = "英语",

volume = "17",

pages = "933--936",

journal = "Chinese Journal of Cancer Prevention and Treatment",

issn = "1673-5269",

publisher = "Chinese Journal of Cancer Prevention and Treatment, Editorial board",

number = "12",

}

TY - JOUR

T1 - Correlation and clinical significance between expression of PIK3CA and drug resistance in colorectal carcinoma tissues

AU - Li, Yang Yang

AU - Wu, Shu Hua

AU - Liu, Lu Ying

AU - Zhu, Yu Hong

PY - 2010/6/28

Y1 - 2010/6/28

N2 - OBJECTIVE: To explor the correlation and clinical significance between the expression of PIK3CA and multidrug resistance gene products LRP, GST-π and Topo II in colorectal carcinoma tissues. METHODS: The expressions of PIK3CA, LRP, GST-π and Topo II in 108 patients with colorectal carcinoma were detected by Max Vision™ immunohistochemical technique. The relationship of PIK3CA and drug resistance in colorectal cancer was analyzed. RESULTS: 1) The PIK3CA expression was correlated with the degree of tumor differentiation, TNM stage and lymph node metastasis (P<0.05); 2) The PIK3CA expression was correlated with GST-π and Topo II. CONCLUSION: The PIK3CA expression is correlated with MDR, therefore, detecting the expressions of PIK3CA has the important significance with regard to choosing the individual chemotherapy and prediction of prognosis.

AB - OBJECTIVE: To explor the correlation and clinical significance between the expression of PIK3CA and multidrug resistance gene products LRP, GST-π and Topo II in colorectal carcinoma tissues. METHODS: The expressions of PIK3CA, LRP, GST-π and Topo II in 108 patients with colorectal carcinoma were detected by Max Vision™ immunohistochemical technique. The relationship of PIK3CA and drug resistance in colorectal cancer was analyzed. RESULTS: 1) The PIK3CA expression was correlated with the degree of tumor differentiation, TNM stage and lymph node metastasis (P<0.05); 2) The PIK3CA expression was correlated with GST-π and Topo II. CONCLUSION: The PIK3CA expression is correlated with MDR, therefore, detecting the expressions of PIK3CA has the important significance with regard to choosing the individual chemotherapy and prediction of prognosis.

KW - Colorectal carcinoma

KW - GST-π

KW - LRP

KW - PIK3CA

KW - Topo II

UR - https://www.scopus.com/pages/publications/77957926527

M3 - 文章

AN - SCOPUS:77957926527

SN - 1673-5269

VL - 17

SP - 933

EP - 936

JO - Chinese Journal of Cancer Prevention and Treatment

JF - Chinese Journal of Cancer Prevention and Treatment

IS - 12

ER -

Correlation and clinical significance between expression of PIK3CA and drug resistance in colorectal carcinoma tissues

摘要

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