fiL清单胺氧化丨悔与儿童青少年肥胙 之问的关系研究

Objective To explore the relationship between serum monoamine oxidase level and obesity in children and adolescents and its correlation with cardiovascular and metabolic indexes,so as to provide theoretical basis for prevention and treatment of obesity and its related complications. Methods Totally 1 007 middle school students from Shenyang city were enrolled in this study to perform physical examination from April to Norember 2018,including body measurements and serum biochemical tests. And the results were analyzed according to different levels of obesity group. Results The rate of obesity was 14.40%,which was significantly higher in boys (16.33%) than girls (12.48%). One-way ANOVA showed that of the serum monoamine oxidase level of the obese group was higher than that of the normal by 16.32%[(8.48±2.10) U/L for obese group and (7.29±3.02) U/L for normal group,F=9.874,P<0.001].Logistic regression analysis showed that the increase of serum monoamine oxidase was a risk factor for obesity(OR=1.13,95%CI:1.06-1.20,P<0.001). Linear correlation and regression analysis showed that the serum monoamine oxidase level was correlated with body mass index(β=0.083,95%CI:0.025-0.140,P=0.005) and AST level (β=0.039,95%CI:0.003-0.075,P=0.032). Conclusion Serum monoamine oxidase might be involved in some physiological processes related to obesity such as fat metabolism and sugar metabolism,so that the increase of serum monoamine oxidase is a risk factor for obesity.